Dr.Ravi Shankar L.

Dr.Ravi Shankar L.
Professional Experience
 
  • Principal Scientist (CSIR-NIIST)
  • Senior Scientist (CSIR-NIIST)
  • Scientist (CSIR-NIIST)
  • Guest faculty at IISER – Thiruvananthapuram
  • DST Fast track Young Scientist (CSIR-NIIST) 
  • Adjunct Assistant Professor, Queens College of CUNY
  • Postdoctoral research, Queens College of CUNY 
  • Dec 2019-Present
  • Dec 2015-Dec 2019
  • Dec 2011-Dec 2015
  • Varsha semester 2015
  • 2010-2011
  • 2009-2010
  • 2009-2010
Achievements & Awards

Awards and Fellowships

  • Kerala State Young Scientist Award                                                       2013
    By the Kerala State Council for Science, Technology and Environment (KSCSTE)
  • SERC Fasttrack fellowship for Young Scientist                                    2011
    From Department of Science and Technology, Govt. of India
  • Dr. Rose Kfar Rose Dissertation Award                                                 2008
    Dissertation Award from The Graduate Center, CUNY
  • CUNY University fellowship                                                            2005-2006
    Fellowship from The Graduate Center, CUNY
  • Science fellowship from CUNY                                                   2003-2005
    Fellowship from The Graduate Center, CUNY
Publications

Papers Published

2023

  • Isolation of two new stereochemical variants of streptophenazine by cocultivation of Streptomyces NIIST-D31, Streptomyces NIIST-D47, and Streptomyces NIIST-D63 strains in 3C2 combinations - The Journal of Antibiotics 2023. DOI: 10.1038/s41429-023-00638-7.
    D. K. Induja, A. R. S. Jesmina, Manu M. Joseph, Shanmughan Shamjith, Nagaraja Ingaladal, Kaustabh Kumar Maiti, B. S. Dileep Kumar, and Ravi S. Lankalapalli*
  • A potent bioactive fraction against colon cancer from Plectranthus vettiveroides - Exploration of Targeted Anti-tumor Therapy 2023, 4, 227-239. DOI: 10.37349/etat.2023.00131. Faisal M. Athikkavil, Sreekumar U. Aiswarya, Remya Johny, Meghna Sudhesh, Amrutha A. Nisthul, Ravi S. Lankalapalli, Ruby J. Anto*, Smitha V. Bava*
  • In vitro antibacterial effects of combination of ciprofloxacin with compounds isolated from Streptomyces luteireticuli NIIST-D75 - The Journal of Antibiotics 2023. DOI: 10.1038/s41429-023-00600-7.
    Abdul Rasheed Safiya Jesmina, D. K. Induja, Thankappan Drissya, Chakiniplackal Rajan Sruthi, Kozhiparambil Gopalan Raghu, Shijulal Nelson-Sathi, Bhaskaran Nair Saraswathy Amma Dileep Kumar* and Ravi S. Lankalapalli*
  • NMR-based phytochemical profiling of palmyra palm syrup infused with dry ginger, black pepper, and long pepper - Current Nutraceuticals 2023. DOI: 10.2174/2665978604666230112144757.
    Ambili Sasikumar Athira, Ramkumar Kiruthika, Nagaraja Ingaladal, K. A. Krishnakumar, Natakkakath Kaliyathan Raveena, Biju Gopika, Mullan Velandy Reshma and Ravi Shankar Lankalapalli*

2022

  • A pentacarbomethoxycyclopentadiene (PCCP) organic Brønsted acid catalyzed stereoselective glycosidation of N-pentenyl orthoesters (NPOE) of d-glucose and d-galactose, in conjunction with N-iodosuccinimide - Carbohydrate Research 2022. DOI: 10.1016/j.carres.2022.108684.
    Maniyamma Aswathy, Balan Abhijith, Ravi S. Lankalapalli* and Kokkuvayil V. Radhakrishnan*
  • A novel aureothin diepoxide derivative from Streptomyces sp. NIIST-D31 strain - Journal of Antibiotics 2022.  DOI: 10.1038/s41429-022-00547-1.
    Thankappan Drissya, Dehannath Kottaram Induja, M. S. Poornima, A. R. S. Jesmina, Bernard Prabha, Mathew Saumini, Cherumuttathu H. Suresh, K. G. Raghu, B. S. Dileep Kumar, and Ravi S. Lankalapalli*
  • Design, synthesis, and preliminary immunopotentiating activity of new analogues of nojirimycin - Carbohydrate Research 2022, 511, 108479. DOI: 10.1016/j.carres.2021.108479.
    Arun K. Thangarasu, Shainy Sambyal, Halmuthur Mahabalarao Sampath Kumar* and Ravi S. Lankalapalli*
  • Phytochemical investigation of unripe banana (Musa AAB) cv. Nendran and its novel ‘Banana Grits’ – Food Chemistry Advances 2022. DOI: 10.1016/j.focha.2022.100063.
    Natakkakath Kaliyathan Raveena, Nagaraja Ingaladal, M. V. Reshma,* and Ravi S. Lankalapalli*
  • Studies on the mode of action of synthetic diindolylmethane derivatives against triple negative breast cancer cells – Basic & Clinical Pharmacology & Toxicology 2022. DOI: 10.1111/bcpt.13767.
    Ganesan Shilpa, Sreerenjini Lakshmi, Vellekkatt Jamsheena, Ravi Shankar Lankalapalli, Ved Prakash, Anbumani Sadasivam and Sulochana Priya
  • Synthesis of Immucillins BCX-1777 and BCX-4430 from a Common Precursor - European Journal of Organic Chemistry 2022. DOI: 10.1002/ejoc.202200428.
    K. A. Krishnakumar and Ravi S. Lankalapalli*
  • Cucurbitacin B, Purified and Characterized From the Rhizome of Corallocarpus epigaeus Exhibits Anti-Melanoma Potential - Frontiers in Oncology 2022. DOI: 10.3389/fonc.2022.903832.
    Sreekumar Usha Devi Aiswarya, Gowda Vikas, Nair Hariprasad Haritha, Vijayasteltar Belsamma Liju, Anwar Shabna, Mundanattu Swetha, Tennyson Prakash Rayginia, Chenicheri Kizhakkeveettil Keerthana, Lekshmi Raghu Nath, Mullan Vellandy Reshma, Sankar Sundaram, Nikhil Ponnoor Anto, Ravi Shankar Lankalapalli*, Ruby John Anto and Smitha Vadakkeveettil Bava
  • Augmented Efficacy of Uttroside B over Sorafenib in a Murine Model of Human Hepatocellular Carcinoma -Pharmaceuticals 2022, 15, 636. DOI: 10.3390/ph15050636.
    Mundanattu Swetha, Chenicheri K. Keerthana, Tennyson P. Rayginia, Lekshmi R. Nath, Nair Hariprasad Haritha, Anwar Shabna, Kalishwaralal Kalimuthu, Arun K. Thangarasu, Sreekumar U. Aiswarya, Somaraj Jannet, Sreekumar Pillai, Kuzhuvelil B. Harikumar, Sankar Sundaram, Nikhil Ponnoor Anto, Dee H. Wu, Ravi S. Lankalapalli, Rheal Towner, Noah Isakov, Sathyaseelan S. Deepa and Ruby John Anto
  • Enzyme based bioelectrocatalysis over laccase immobilized poly-thiophene supported carbon fiber paper for the oxidation of D-ribofuranose to D-ribonolactone - Molecular Catalysis 2022, 524, 112314. DOI: 10.1016/j.mcat. 2022.112314.
    Ditto Abraham Thadathil, Anitha Varghese, Chekrain Valappil Shihas Ahamed, K. A. Krishnakumar, Sanjay Suresh Varma, Ravi S. Lankalapalli and Kokkuvayil Vasu Radhakrishnan
  • Augmented efficacy of uttroside B over sorafenib in a murine model of human hepatocellular carcinoma - bioRxiv 2022. DOI: 10.1101/2022.02.01.478749.
    Mundanattu Swetha, C.K. Keerthana, Tennyson P Rayginia, Lekshmi R Nath, Nair Hariprasad Haritha, Kalishwaralal Kalimuthu, Somaraj Janet, Sreekumar Pillai, Kuzhuvelil B Harikumar, Sankar Sundaram, Nikhil Ponnoor Anto, Dee H Wu, Ravi Shankar Lankalapalli, Rheal Towner, Noah Isakov, Deepa Sathyaseelan, Ruby John Anto
  • Blockade of Uttroside B-Induced Autophagic Pro-Survival Signals Augments Its Chemotherapeutic Efficacy Against Hepatocellular Carcinoma - Frontiers in Oncology 2022. DOI: 10.3389/fonc.2022.812598.
    Lekshmi R. Nath, Mundanattu Swetha, Vinod Vijayakurup, Arun Kumar Thangarasu, Nair Hariprasad Haritha, Anwar Shabna, Sreekumar U. Aiswarya, Tennyson P. Rayginia, C. K. Keerthana, Kalishwaralal Kalimuthu, Sankar Sundaram, Ravi Shankar Lankalapalli, Sreekumar Pillai, Rheal Towner, Noah Isakov and Ruby John Anto

2021

  • Transition Metal/Lewis Acid Catalyzed Reactions of Zerumbone for Diverse Molecular Motifs - The Chemical Record 2021. DOI: 10.1002/tcr.202100206
    Mohanan Biji, Bernard Prabha, Ravi S. Lankalapalli* and Kokkuvayil Vasu Radhakrishnan*
  • A Cu(I)-azidopyrrolo[3,2-d]pyrimidine catalyzed Glaser-Hay reaction under mild conditions - ACS Organic & Inorganic Au 2021. DOI: 10.1021/acsorginorgau.1c00015
    Arun K. Thangarasu, Velickakathu O. Yadhukrishnan, K. A. Krishnakumar, Sanjay Suresh Varma, Ravi Shankar Lankalapalli*
  • Tandem Photoisomerization and Transannular Cyclizations of Zerumbone Epoxide: A Model for Diversity-Oriented Synthesis using Abundant Natural Products - Organic Letters 2021, 23, 5871-5875. DOI: 10.1021/acs.orglett.1c01997
    Mohanan Biji, Kokkuvayil Vasu Radhakrishnan* and Ravi Shankar Lankalapalli*
  • Mirabijalones S-W, rotenoids from rhizomes of white Mirabilis jalapa Linn. and their cell proliferative studies - Phytochemistry Letters 2021, 44, 178-184. DOI: 10.1016/j.phytol.2021.06.017.
    P. Sharathna, V. Alisha, P. Sasikumar, Ajesh Vijayan, F. Ayisha, I.G. Shibi, V.V. Sivan, Kaustabh Kumar Maiti, Ravi S. Lankalapalli, K.V. Radhakrishnan*

2020

  • Dienaminodiones, new push-pull alkenes, from 3,4-dihydroxysalicylaldehyde-derived Schiff base -Tetrahedron Letters 2020.  DOI: 10.1016/j.tetlet.2020.152531.Jaice Ravindran, Nagaraja Ingaladal and Ravi Shankar Lankalapalli*
  • Spice-infused palmyra palm syrup improved cell-mediated immunity in Wistar Albino rats - Journal of Food Biochemistry 2020. DOI: 10.1111/jfbc.13466.
    Suja Somasekharan Nair Rajam,* Krishnakumar Neenthamadathil Mohandas, Habeeba Vellolipadikkal, Syamnath Viswanathan Leena, Veena Kollery Suresh, Raveena Natakkakath Kaliyathan, Rajasekharan Sreedharan Nair, Ravi Shankar Lankalapalli* and Reshma Mullan Velandy*
  • Putative biomimetic route to 8-oxabicyclo[3.2.1]octane motif from a humulene sesquiterpenoid zerumbone -Organic Letters 2020. DOI: 10.1021/acs.orglett.0c02220.
    Kollery S. Veena, Greeshma Gopalan, Murali Madhukrishnan, Sunil Varughese, Kokkuvayil Vasu Radhakrishnan* and Ravi Shankar Lankalapalli*
  • The assembly of glycosphingolipid determines their immunomodulatory effect: A novel method for structure-based design of immunotherapy - Cellular Immunology 2020. DOI: 10.1016/j.cellimm.2020.104157. Tomer Adar, Ravi Shankar Lankalapalli, Robert Bittman, Yaron Ilan.
  • Semi-synthetic diversification of Coronarin D, a Labdane Diterpene, under Ugi Reaction Conditions - Natural Product Research 2020. DOI: 10.1080/14786419.2020.1782406. Kollery Veena, Murikkinthara Taniya, Jaice Ravindran, Arun Kumar Thangarasu, Sulochana Priya & Ravi Shankar Lankalapalli*
  • Dienaminodioate based multicomponent reactions with post-benzylic oxidative transformations mediated by
    DDQ - Org. Biomol. Chem. 2020, 18, 3927–3937.  DOI: 10.1039/D0OB00721H. Jaice Ravindran, Velickakathu Yadhukrishnan, Reghuvaran Asha and Ravi Shankar Lankalapalli*
  • Synthesis of 2, 5-Diamino-p-benzoquinones via Aerobic Oxidative C(sp2)-C(sp2) Bond Cleavage and Mechanistic Studies - Chemistry Select 2020, 5, 2545-2550. DOI: 10.1002/slct.201904948. Anandavally Asha, Jaice Ravindran, Subhadra Suma, Cherumuttathu H. Suresh,* and Ravi S. Lankalapalli*

2018

  • Syzygium cumini seed exhibits antidiabetic potential via multiple pathways involving inhibition of a-glucosidase, DPP-IV, glycation, and ameliorating glucose uptake in L6 cell lines - J. Food Process. Preserv. 2018, 42, e13464.
    Syama, Hari Priya; Arun, Karthika Bahulayan; Sinumol, George; Dhanya, Rajendran; Suseela Anusree, Sasidharan; Nisha, P.; Ravi Shankar Lankalapalli; Sundaresan, Andikanan; Jayamurthy, Purushothaman
  • New 1,2-dihydropyridine based fluorophores and their applications as fluorescent probes - ACS Omega 2018
    [DOI: 10.1021/acsomega.7b01835].
    Vellekkatt Jamsheena, Rakesh K. Mishra, Kollery S. Veena, Suresh Sini, Purushothaman Jayamurthy* and Ravi S. Lankalapalli*
  • Polyhydroxy-N- alkyl-2- pyrrolidinones as a new class of glycolipid analogues with immune modulation potential
    - J. Carb. Chem. 2018[DOI: 10.1080/07328303.2017.1413193].
    Srinivasa Reddy Bonam, Jaggaiah Naidu Gorantla, Arun Kumar Thangarasu, Ravi S. Lankalapalli* and Halmuthur Mahabalarao Sampath Kumar *

2017

  • Metal-free diaryl etherification of tertiary amines by ortho-C(sp2)-H functionalization for synthesis of dibenzoxazepines and – ones – Org. Lett. 2017 [DOI: 10.1021/acs.orglett.7b03328].Vellekkatt Jamsheena, Chikkagundagal K. Mahesha, M. Nibin Joy, Ravi S. Lankalapalli*
  • An expedient synthesis of indolo[2,3-b]quinolines, chromeno[2,3-b]indoles, and 3-alkenyl-oxindoles from 3,3′-diindolylmethanes and evaluation of their antibiotic activity against methicillin-resistant Staphylococcus aureus - ACS Omega 2017 [DOI: 10.1021/acsomega.7b00840].
    Chandrasekhar Challa, Jaice Ravindran, Mohini Mohan Konai, Sunil Varughese, Jubi Jacob, B. S. Dileep Kumar, Jayanta Haldar, Ravi S. Lankalapalli*
  • Metal-Free Multiple Carbon?Carbon and Carbon?Hydrogen Bond Activations via Charge-Switching Mechanism in Unstrained Diindolylmethanes - Org. Lett. 2017 [DOI: 10.1021/acs.orglett.7b01843].
    Chandrasekhar Challa, Sunil Varughese, Cherumuttathu H. Suresh,* Ravi S. Lankalapalli*
  • Anti-Mycobacterial activity of Chrysomycin A produced by Streptomyces sp. OA161 isolated from coastal Kerala – RSC Advances 2017, 7, 36335-36339.
    Balaji Muralikrishnan, Vipin Mohan Dan, Vinodh J S, Vellekkatt Jamsheena, Ranjit Ramachandran, Sabu Thomas, Syed G Dastegar, K Santhosh Kumar, Ravi S. Lankalapalli, Ramakrishnan Ajay Kumar
  • First report on isolation of 2,3,4-trihydroxy-5-methylacetophenone from palmyra palm (Borassus flabellifer Linn.) syrup, its antioxidant and antimicrobial properties - Food Chem. 2017, 228, 491-496.
    M. V. Reshma*, Jubi Jacob, V. L. Syamnath, V. P. Habeeba, B. S. Dileep Kumar, Ravi S. Lankalapalli*

2016

  • Evaluation of uttroside B, a saponin from Solanum nigrum Linn, as a promising chemotherapeutic agent against hepatocellular carcinoma - Sci. Rep.2016, [DOI: 10.1038/srep36318].
    Lekshmi R. Nath, Jaggaiah N. Gorantla, Arun Kumar T. Thulasidasan, Vinod Vijayakurup, Shabna Shah, Shabna Anwer, Sophia M. Joseph, Jayesh Antony, Kollery Suresh Veena, Sankar Sundaram, Udaya K. Marelli, Ravi S. Lankalapalli,* Ruby John Anto*
  • Anticancer activity of synthetic bis(indolyl)methane-ortho-biaryls against human cervical cancer (HeLa) cells - Chem. -Biol. Interact. 2016, 247, 11-21.
    Vellekkatt Jamsheena, Ganesan Shilpa, Jayaram Saranya, Nissy Ann Harry, Ravi S. Lankalapalli,* Sulochana Priya*
  • Introduction to the Robert Bittman memorial issue - Chem. Phys. Lipids 2016, 194, 1.
    Gemma Fabrias, Alexander Greer, Ravi S. Lankalapalli, Robert Engel
  • Design and synthesis of a novel glycosphingolipid derived from polyhydroxy 2-pyrrolidinone and phytoceramide appended by a 1,2,3-triazole linker - Chem. Phys. Lipids 2016, 194, 158-164.
    Jaggaiah N. Gorantla, A. Faseela, Ravi S. Lankalapalli*

2015

  • Kaempferide, the most active among the four flavonoids isolated and characterized from Chromolaena odorata, induces apoptosis in cervical cancer cells while being pharmacologically safe - RSC Advances 2015, 5, 100912-100922.
    Lekshmi R. Nath, Jaggaiah N. Gorantla, Sophia Margaret Joseph, Jayesh Antony, Sanu Thankachan, Darsan B. Menon, S. Sankar, Ravi S. Lankalapalli,* Ruby John Anto*
  • Characterization of the Bioactive Metabolites from a Plant Growth-Promoting Rhizobacteria and Their Exploitation as Antimicrobial and Plant Growth-Promoting Agents - Appl. Biochem. Biotechnol. 2015, 176, 529-546.
    Emrin George, Nishanth S. Kumar, Jubi Jacob, Bhaskara Bommasani, Ravi S. Lankalapalli, P. Morang, B. S. Dileep Kumar
  • A Novel 2-alkoxy-3, 5-dihydroxypyridine mediated regulation of gelatinases - Int. J. Pharma Bio Sci. 2015, 6, 1435-1444.
    Jyotsna Nambiar, Geetha B. Kumar, Sanjana S. R., Jaggaiah N. Gorantla, Ravi S. Lankalapalli and Bipin G. Nair

2014

  • A metal-free one-pot cascade synthesis of highly functionalized biaryl-2-carbaldehydes - Org. Biomol. Chem. 2014 (DOI: 10.1039/C4OB01829J).
    Chandrasekhar Challa, Jamsheena Vellekkatt, Jaice Ravindran, Ravi S. Lankalapalli*
  • Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L - A hybrid design approach - Chem. Commun. 2014, 50, 10875-10878
    Dibyendu Dana, Shatarupa De, Pratikkumar Rathod, Anibal R. Davalos, Daniel A. Novoa, Suneeta Paroly, Viviana M. Torres, Nisar Afzal, Ravi S. Lankalapalli, Susan A. Rotenberg, Emmanuel J. Chang, Gopal Subramaniama, Sanjai Kumar
  • Synthesis of beta-C-galactosyl ceramide and its new aza variant via Horner-Wadsworth-Emmons reaction – J. Org. Chem. 2014, 79, 5193-5200.
    Jaggaiah N. Gorantla, Ravi S. Lankalapalli*
  • Cytotoxicity studies of semi-synthetic derivatives of theveside derived from the aqueous extract of leaves of ‘suicide tree’ Cerbera odollam - Nat. Prod. Res. 2014, 28, 1507-1512.
    Jaggaiah N. Gorantla, Jamsheena Vellekkatt, Lekshmi R. Nath, Ruby John Anto, Ravi S. Lankalapalli*
  • Purification and characterization of antifungal phenazines from a fluorescent Pseudomonas strain FPO4 against medically important fungi - J. Mycol. Med. 2014 (DOI: 10.1016/j.mycmed.2014.02.003)
    Jaggaiah N. Gorantla; Nishanth Kumar S; Nisha G. V.; Sumandu A. S.; Dileep C.; Sudaresan A.; Sree Kumar M. M.; Ravi S. Lankalapalli; Dileep Kumar B. S.
  • In vitro antibacterial screening of six proline based cyclic dipeptides in combination with beta-lactam antibiotics against medically important bacteria - Appl. Biochem. Biotechnol. 2014, 173, 116-128.
    Nishanth Kumar S, Ravi S. Lankalapalli, Dileep Kumar B S
  • Synergistic activity of phenazines isolated from Pseudomonas aeruginosa in combination with azoles against Candida species - Medical mycology 2014, 52, 482-490.
    S. Nishanth Kumar, G. V. Nisha, A. Sudaresan, V. V. Venugopal, M. M. Sree Kumar, Ravi S. Lankalapalli, B. S. Dileep Kumar
  • A comparative study of antimicrobial properties of cyclo(L-Pro- L-Asp) with its 2-ketopiperazine analog - Med. Chem. Res. 2014, 23, 2377-2385.
    Chandrasekhar Challa, Nishanth Kumar, Manju John, Ravi S. Lankalapalli*

2013

  • Cascade synthesis of 1,2-Dihydropyridine from dienaminodioate and an imine: A Threecomponent approach - Tetrahedron Lett. 2013, 54, 3810-3812.
    Chandrasekhar Challa, Manju John, Ravi S. Lankalapalli*
  • Isolation and antifungal properties of cyclo(D-Tyr- L-Leu) diketopiperazine isolated from Bacillus sp. associated with rhabditid entomopathogenic nematode – Nat. Prod. Res. 2013, 27, 2168-2172.
    Nishanth Kumar, Jaggaiah N. Gorantla, C. Mohandas, Bala Nambisan, Ravi S. Lankalapalli*
  • An unusual synthesis of 2-pyridone and 3,5-dihydroxypyridine from a carbohydrate - Tetrahedron Lett. 2013, 54, 3230-3232.
    Jaggaiah N. Gorantla, Divya Kovval, Ravi S. Lankalapalli*
  • Ceramide 1-phosphate stimulates glucose uptake in macrophages - Cell Signal. 2013, 25, 786-795.
    Alberto Ouro, Lide Arana, Patricia Gangoiti, Io-Guane Rivera, Marta Ordonez, Miguel Trueba, Ravi S. Lankalapalli, Robert Bittman, Antonio Gomez-Munoz.
  • Isolation of proline-based cyclic dipeptides from Bacillus sp. N strain associated with rhabditid entomopathogenic nematode and its antimicrobial properties - World J Microbiol Biotechnol. 2013, 29, 355-364.
    Nishanth Kumar, C. Mohandas, Bala Nambisan, D. R. Soban Kumar, Ravi S. Lankalapalli*

2008 – 2012

  • Generation of reactive oxygen species (ROS) is a key factor for stimulation of macrophage proliferation by ceramide 1-phosphate - Exp.Cell. Res. 2012, 318, 350-360.
    Lide Arana, Patricia Gangoiti, Alberto Ouro, Io-Guané Rivera, Marta Ordoñez, Miguel Trueba, Ravi S. Lankalapalli, Robert Bittman, Antonio Gomez-Muñoz.
  • Synthesis and Properties of a Photoactivatable Analog of Psychosine (beta?Galactosylsphingosine) - ChemMedChem 2010, 5, 682-686.
    Ravi S. Lankalapalli, Attila Baksa, Karoly Liliom, Robert Bittman.
  • Caged Ceramide 1-Phosphate Analogues: Synthesis and Properties - J. Org. Chem. 2009, 74, 8844-8847.
    Ravi S. Lankalapalli, Alberto Ouro, Lide Arana, Antonio Gómez Muñoz, Robert Bittman.
  • Synthesis and Antioxidant Properties of an Unnatural Plasmalogen Analogue Bearing a trans O-Vinyl Ether Linkage - Organic Letters 2009, 11, 2784-2787.
    Ravi S. Lankalapalli, Joseph T. Eckelkamp, Debajit Sircar, David A. Ford, Papasani V. Subbaiah, Robert Bittman.
  • Effect of Double Bond Geometry in Sphingosine Base on the Antioxidant Function of Sphingomyelin - Arch. Biochem. Biophys. 2009, 481, 72-79.
    Papasani V. Subbaiah, Debajit Sircar, Ravi S. Lankalapalli, Robert Bittman.
  • Raftlike Mixtures of Sphingomyelin and Cholesterol Investigated by Solid-State 2H NMR Spectroscopy - J. Am. Chem. Soc. 2008, 130, 14521-14532.
    Tim Bartels, Ravi S. Lankalapalli, Robert Bittman, Klaus Beyer, Michael F. Brown.
  • (Coumarin-4-yl) methyl esters as cages of phosphosphingolipid second messengers. Abstracts of Papers, 236th ACS National Meeting, Philadelphia, PA, United States, August 17, 2008.
    Ravi S. Lankalapalli, Robert Bittman
Academic Qualification
  • PhD The Graduate Center, City University of New York (CUNY)                                2009
    Dissertation: “Synthesis of Analogs of Sphingophospholipids, Glycolipids and Plasmalogen”
    Advisor: Distinguished Professor Robert Bittman
  • M.Phil. The Graduate Center, City University of New York (CUNY)                           2005
    Subject: Chemistry
  • M.Sc. Andhra University, India                                                                                    2001
    Subject: Organic Chemistry
  • B.Sc. Andhra University, India                                                                                    1999
    Subject: Maths, Physics and Chemistry
Research Interest

Research Interest

Isolation and structure elucidation of natural products from plants, microbes and food sources, and exploration of their biological activity; total synthesis of natural products and analogs; development of novel synthetic methods for natural product-based medchem library; synthesis of glycoconjugates; and process chemistry for APIs and chemical intermediates.

Extramural Projects

Completed Extramural Projects as PI

  • Synthesis of iminosugar variants of alpha-Galactosyl ceramide for tuning of selective cytokine release from natural killer T (NKT) cells – (DST, Jan 2011 to Jan 2014)
  • Synthetic utility of dienaminodioate for synthesis of 1,2-dihydropyridines and its resulting derivatives for evaluation of their biological properties – (KSCSTE, Apr 2014 to Apr 2018)
  • Synthesis of a library of Aza-C-KRN7000 and Aza-galactolipid analogues for immunomodulatory screening – (DST, Oct 2015 to Mar 2019)
  • Development of synthetic strategies for diverse compound collection of privileged structural motifs for medicinal chemistry – (KSCSTE, Jan 2016 to Dec 2019)
  • Exploration of the structures and bioactivities of semi-synthetic and glycoside derivatives of abundant natural products from the Western Ghats of India and East Java, Indonesia – (DST, Sep 2019 to Sep 2021)
  • New therapeutics against SARS Cov2: analysing small molecule chemical libraries by establishing targeted cell-based assays for inhibitors of viral entry & viral protease – (DBT, Nov 2020 to Nov 2021)

Industrial Projects with (a) M/s. Apicore Pharmaceuticals Pvt. Ltd. (b) M/s Omgene Life Sciences Pvt. Ltd.

Ongoing Extramural Projects as PI

  • Design and synthesis of novel iminosugar variants and their cationic amphiphiles as antiviral therapeutics against Dengue Virus (DENV) – (DBT, Oct 2020 to Oct 2023)
  • Synthesis of a novel lipid-linked oligosaccharide and its evaluation as vaccine adjuvant – (DST, Dec 2020 to Dec 2023)
  • Synthesis of novel pyrrolidine-based antivirals against Dengue Virus – (ICMR, Feb 2023 to Feb 2026)