Dr.Kaustabh Kumar Maiti

Dr.Kaustabh Kumar Maiti

Kaustabh Kumar Maiti obtained B.Sc Chemistry (Honours) & M.Sc. in organic chemistry (specialization) from University of Calcutta (India) and thereafter awarded Ph.D from the same university in the year 2001. His Ph.D work based on development of synthetic methodologies of regio- and stereo-selective nitrogenous heterocycles by 1,3-dipolar nitrone cycloaddition with a wide variety of synthetic and naturally occurring diplorophiles. He started his professional carrier in leading pharmaceutical R&D’s in India, 2000-2003 (Alembic Ltd. and Sun Pharmaceuticals Industries Ltd.) where he worked in process development of generic drugs and drug discovery program. After industrial training, he joined postdoctoral research at Pohang University of Science and Technology (POSTECH, 2003-2007), South Korea, with Prof. Sung-Kee Chung and developed a series of novel non-peptide drug delivery system (DDS) using inositol and carbohydrate as scaffold. He moved to Complex Cabohydrate Research Center (CCRC), The University of Georgia, USA to continue second postdoctoral research. In CCRC he worked Prof. Geert-Jan Boons’s group (2007  -2009) in the field of glycopeptide, structural aspects of peptidoglycan and LPS. Before joining at CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, he engaged at Singapore Bioimaging Consortium (under Biomedical Sciences Institute, A*STAR) as a research scientist (2009-2012) and explored surface enhanced Raman scattering (SERS) platform and SERS-nanoparticle tags as diagnostic tool for detection and imaging of cancer biomarkers. His current research interest focused on synthesis and biological evaluation of synthetic (peptide, non-peptide, dendron based scaffold ) and nano-carrier based drug-delivery system (DDS) for targeted delivery of small molecular drugs, proteins, nucleic acids and plasmid DNA.  Also his interest on the development of multimodal theranostic nanoprobe for infectious diseases as well as cancer detection and imaging by SERS, fluorescence, MRI, photoacoustic as diagnostic modalities and PDT, PTT and combined chemo-immuno therapy. Presently his group initiated on natural product derived new phyto chemical entities (NPCEs) towards Hit / advanced Hit generation in cancer therapy.

http://niist.irins.org/profile/64932

Professional Experience

Professional and Postdoctoral Experience

  • Senior Principal Scientist and Head Organic Chemistry
    April, 2020 - to date
    Chemical Science and Technology Division (CSTD)
    National Institute for Interdisciplinary Science and Technology (NIIST),
    Council of Scientific and Industrial Research (CSIR), Govt. of India
    Thiruvinanthapuram, India
  • Principal scientist
    April, 2015 -  April, 2020
    Chemical Science and Technology Division (CSTD)
    National Institute for Interdisciplinary Science and Technology (NIIST),
    Council of Scientific and Industrial Research (CSIR), Govt. of India
    Thiruvinanthapuram, India
  • Senior Scientist
    April, 2012 - April, 2015
    Chemical Science and Technology Division (CSTD)
    National Institute for Interdisciplinary Science and Technology (NIIST),
    Council of Scientific and Industrial Research (CSIR), Govt. of India
    Thiruvinanthapuram, India
  • Research Scientist
    May, 2009 - March, 2012
    Biomedical Sciences Institutes (A*STAR)
    Singapore Bioimaging Consortium (SBIC), Biopolis, Singapore
  • Postdoctoral Research Associate
    May 2007 - April, 2009
    Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA
  • Postdoctoral Research Scientist
    May 2003 - April, 2007
    Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang,
    South Korea
  • Executive, Discovery R&D
    Oct 2000 - April, 2003
    Sun Pharma Advanced Research Center (SPARC),
    Sun Pharmaceutical Industries Ltd., Vadodara, India
  • Research Officer, Chemical Research Division, Process-R&D
    Mar 2000 - Sep 2000
    Alembic Ltd., Vadodara, India

Professional Affiliations

  • Indian Chemical Society : Life Member
  • Chemical Research Society of India (CRSI): Life Member
  • Indian Science Congress Association :Life Member
  • Indian Association for the Cultivation of Science (IACS) :Life Member
Achievements & Awards
  • Service Excellence Award from Singapore Bioimaging Consortium (SBIC) A*STAR, Singapore, 2011
  • CSIR Technology Award, CSIR, Ministry of Science and Technology, Govt. of India, 2020
Patents & Publications

Patents and Conference Presentations

Patents:

  • Nanoformulation screening kit for label free detection of precancerous lesions of cervix   surface enhanced Raman scattering platform and process for the preparation thereof;  Kaustabh Kumar Maiti, K. Sujathan, Varsha Karunakaran;  International Patent Application No: PCT/IN2019/050540, dated 24.07.2019.
  • A Diagnostic screening kit for simultaneous detection of clinically relevant biomarkers from breast cancer tissue samples using surface enhanced Raman scattering platform and process for the preparation thereof; Kaustabh Kumar Maiti, K. Sujathan, Vishnu Priya Murali, Varsha K, Deepika S, Madhukrishnan M ; Indian Patent Application ref. No. 0137NF2019 dated 26.08.2019.
  • A Universal Silica Coating Method for Large-scale and Environmentally Friendly Production of Highly Sensitive SERS Nanotags in Aqueous Solutions; Liu Shuhua, Kaustabh Kumar Maiti, Shah Kwok Wei, Low Michelle, She Zhi Wei, Han Ming- Yong, Soh Kiat Seng Jason, U. S. Dinish, Malini Olivo, Young-Tae Chang; US Provisional Patent Ref no.:IMRE/09-8C0202; date: 10th Sep., 2011.
  • Surface enhanced Raman spectroscopy (SERS) compounds and methods of their preparation; Young Tae Chang, Kaustabh Kumar Maiti , U.S. Dinish, Chit Yaw Fu, Malini Olivo, Soh Kait Seng Jason, Seong wook Yun; U.S. Pat. Appl. Publ. (2012), 73pp., Pub. No.: US 2012/0128592 A1; Pub. Date: May, 24, 2012.
  • Development of Photostable Near-IR Cyanine Dyes for In Vivo Imaging.Young-Tae Chang, Animesh Samanta, Marc Vendrell, N. Y. Kang, Kaustabh Kumar Maiti, U.S. Dinish, Malini Olivo, K. S. Soh; US Provisional Patent Appl. No. : 61/317109; dated 04-03-2010.
  • Inositol based molecular transporters and processes for the preparation thereof,Sung-Kee Chung, Kaustabh K Maiti, Jeon Ock Youm, Seok-Ho Yu ; Korea patent, Patent No. 10-0578732, The Application No. 2004-0014833 (2004.03.05).
  • Inositol based molecular transporters and processes for the preparation thereof, Sung-Kee Chung, Kaustabh K Maiti, Jeon Ock Youm, Seok-Ho Yu;PCT Int.Appl.(2005), 58pp. CODEN:PIXXD2 WO 2005/085159 A1 20050915 AN 2005: 1004682 CAPLUS.
  • Inositol based molecular transporters and processes for the preparation thereof, Sung-Kee Chung, Kaustabh K Maiti, Jeon Ock Youm, Seok-Ho Yu ;U.S. Pat. Appl. Publ. (2006), 25pp., Pub. No.: US 2006/0280796 A1; Pub. Date: Dec. 14, 2006.
  • Molecular transporters based on sugar or its analogues and processes for the preparation thereof”,Sung-Kee Chung, Kaustabh K Maiti, Jeon Ock Youm, Seok-Ho Yu;Korea patent, Patent No. 10-0699279, The Application No. 2005-0035410 (2005.04.28).
  • Molecular transporters based on sugar or its analogues and processes for the preparation thereof”,Sung-Kee Chung, Kaustabh K Maiti, Jeon Ock Youm, Seok-Ho Yu;PCT Int.Appl.(2006), 74pp. CODEN:PIXXD2 WO 2006/115312 A1 20061102 AN 2006: 1155705 CAPLUS.
  • Molecular transporters based on sugar or its analogues and processes for the preparation thereof”, Sung-Kee Chung, Kaustabh K Maiti, Jeon Ock Youm, Seok-Ho Yu;U.S. Patent No.: US 7,846,975 B2, A1; Pub. Date: Dec. 7, 2010.
  • Molecular transporters based on alditol or inositol and processes for the preparation thereof.Sung-Kee Chung, Kaustabh K Maiti, Woo Sirl Lee;  Korea patent, The Application No. 2006-86106 (2006.09.07).
  • Molecular transporters based on alditol or inositol and processes for the preparation thereof.Sung-Kee Chung, Kaustabh K Maiti, Woo Sirl Lee U.S. Pat. Appl. Publ. (2008), 32pp.,Cont.-in-part of U.S. Ser. No. 815,339. CODEN: USXXCO US 2008039421 A1 20080214 Patent written in English.
  • A Universal Silica Coating Method for Large-scale and Environmentally Friendly Production of Highly Sensitive SERS Nanotags in Aqueous Solutions; Liu Shuhua, Kaustabh Kumar Maiti, Shah Kwok Wei, Low Michelle, She Zhi Wei, Han Ming- Yong, Soh Kiat Seng Jason, U. S. Dinish, Malini Olivo, Young-Tae Chang; US Provisional Patent Ref no.:IMRE/09-8C0202; date: 10th Sep., 2011.
  • Surface enhanced Raman spectroscopy (SERS) compounds and methods of their preparation; Young Tae Chang, Kaustabh Kumar Maiti , U.S. Dinish, Chit Yaw Fu, Malini Olivo, Soh Kait Seng Jason, Seong wook Yun; U.S. Pat. Appl. Publ. (2012), 73pp., Pub. No.: US 2012/0128592 A1; Pub. Date: May, 24, 2012.
  • Development of Photostable Near-IR Cyanine Dyes for In Vivo Imaging.Young-Tae Chang, Animesh Samanta, Marc Vendrell, N. Y. Kang, Kaustabh Kumar Maiti, U.S. Dinish, Malini Olivo, K. S. Soh; US Provisional Patent Appl. No. : 61/317109; dated 04-03-2010.
  • Inositol based molecular transporters and processes for the preparation thereof,Sung-Kee Chung, Kaustabh K Maiti, Jeon Ock Youm, Seok-Ho Yu ; Korea patent, Patent No. 10-0578732, The Application No. 2004-0014833 (2004.03.05).
  • Inositol based molecular transporters and processes for the preparation thereof, Sung-Kee Chung, Kaustabh K Maiti, Jeon Ock Youm, Seok-Ho Yu;PCT Int.Appl.(2005), 58pp. CODEN:PIXXD2 WO 2005/085159 A1 20050915 AN 2005: 1004682 CAPLUS.
  • Inositol based molecular transporters and processes for the preparation thereof, Sung-Kee Chung, Kaustabh K Maiti, Jeon Ock Youm, Seok-Ho Yu ;U.S. Pat. Appl. Publ. (2006), 25pp., Pub. No.: US 2006/0280796 A1; Pub. Date: Dec. 14, 2006.
  • Molecular transporters based on sugar or its analogues and processes for the preparation thereof”,Sung-Kee Chung, Kaustabh K Maiti, Jeon Ock Youm, Seok-Ho Yu;Korea patent, Patent No. 10-0699279, The Application No. 2005-0035410 (2005.04.28).
  • Molecular transporters based on sugar or its analogues and processes for the preparation thereof”,Sung-Kee Chung, Kaustabh K Maiti, Jeon Ock Youm, Seok-Ho Yu;PCT Int.Appl.(2006), 74pp. CODEN:PIXXD2 WO 2006/115312 A1 20061102 AN 2006: 1155705 CAPLUS.
  • Molecular transporters based on sugar or its analogues and processes for the preparation thereof”, Sung-Kee Chung, Kaustabh K Maiti, Jeon Ock Youm, Seok-Ho Yu;U.S. Patent No.: US 7,846,975 B2, A1; Pub. Date: Dec. 7, 2010.
  • Molecular transporters based on alditol or inositol and processes for the preparation thereof.Sung-Kee Chung, Kaustabh K Maiti, Woo Sirl Lee Korea patent, The Application No. 2006-86106 (2006.09.07).
  • Molecular transporters based on alditol or inositol and processes for the preparation thereof.Sung-Kee Chung, Kaustabh K Maiti, Woo Sirl Lee U.S. Pat. Appl. Publ. (2008), 32pp.,Cont.-in-part of U.S. Ser. No. 815,339. CODEN: USXXCO US 2008039421 A1 20080214 Patent written in English.

Conference Presentations:

  • ICCHD-2020: International Conference on Chemistry for Human Development Organized by Professor Asima Chatterjee Foundation with University of Calcutta and Heritage Institute of Technology From January 9–11th, 2020 Poster presentations: (I)Biocompactable core Shell polymer based nanocarrier system for the synergestic delivery of embellin and RPI-1to pancreatic adenocarcinoma cells, Arya J. S., Vidyalekshmi MS, V Kaustabh Kumar Maiti. (II)Glycan imbalance in cancer cells monitored by SERS based metabolic labelling Madhukrishnan M., Vishnu Priya Murali, Kaustabh Kumar Maiti (III)Surface charge modulates the internalization vs penetration of nanoparticles: A comprehensive scrutiny on monolayer cells, multicellular spheroids and solid tumor by SERS modality Palasseri T. Sujai, Manu M. Joseph, Giridharan Saranya, and Kaustabh Kumar Maiti (IV) A Two-in-one Theranostic Nanoprobe for The Effective Management of Metastatic Melanoma by Targeted Phototherapy;Shamjith S, Giridharan Saranya , Vishnu Priya Murali , Jyothi B Nair, Manu M Joseph and Kaustabh Kumar Maiti
  • ICEM-14: 14th International Conference on Ecomaterials. Organized by CSIR-NIIST, Thiruvananthapuramin association with National Institute for Materials Science, Japan and Ecomaterials Forum, Japan from Feb 5-7 ,2020 Poster presentation: A Label Free SERS Based Detection of Marker Nucleobases using Complementary Oligonucleotide Strand for Dengue Viral Infection   Selvakumar Deepika, Anjitha Ajith, Vishnu Priya Murali, Varsha Karunakaran and Kaustabh Kumar Maiti (Best poster award)
  • National Conference on New Frontiers in Chemistry – From Fundamentals to Applications (NFCFA2019) (on 20-22 December 2019) at Department of Chemistry, BITS Pilani, K K Birla Goa, Poster presentations Novel Lysosome targeted Fluorescent Probes based on Pyrylium core for monitoring intracellular pH Changes in Living Cells,  Ahammed Shihas, Manu M Joseph, Ramya A.N.,Animesh Samantha and Kaustabh Kumar Maiti.
  • NANOBIOTECK – 2019, 4th Annual Conference of Indian Society of Nanomedicine, (21st – 23rd November 2019) held at Aerocity, New Delhi as a Delegate. Two Poster presentations, (i) VEGF targeted biocompatible nano-carrier system for the sustained release of drug towards diabetic retinopathy, Vidyalekshmi MS, Arya J.S, Kaustabh Kumar Maiti (ii) Best poster award, Sreedevi P ,Jyothi B Nair, Kaustabh Kumar Maiti.
  • 8th Annual Meeting of Indian Academy of Biomedical Sciences, Organised by CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram (Feb 25-27th, 2019); New Phytochemical Entities Derived from Hydnocarpus wightiana Blume Facilitate Mitochondria Mediated Apoptosis Through cyt c Release Monitored By Raman Fingerprint, Invited Talk: Dr. Kaustabh Kumar Maiti. Bimodal Fluorescence-SERS Encoded Nanococktail for the Multiplex Detection of Lung Cancer Biomarkers, Oral Presentation: Saranya Giridharan Engineered Targeted Theranostic Nano Delivery System for Tumor Elimination by Overcoming Drug Resistant Cancer Cells and Cancer Stem Cells, Oral Presentation: Manu M. Joseph. Molecular Probe Based on Tetraphenylethylene (TPE) Utilized for Detection and Signaling Role of Hydrogen Sulfide in Alzheimers Disease, Poster Presentation: Ramya A. N. A Model Study of Label Free SERS Based Detection of Marker Nucleobases Using Complementary Oligonucleotide Strand for Dengue Infection Poster Presentation: Anjitha Ajith. Biogenic Cluster-Encased Gold Nanorods as a Targeted Three-in-One Theranostic Nanoenvelope for SERS-Guided Photochemotherapy against Metastatic Melanoma, Poster Presentation: Sujai P. T. Novel potent anticancer agents derived from hydnocarpin induces mitochondria mediated apoptosis and monitoring cyt c release through Raman fingerprinting, Poster Presentation: Arya J.S. An Effective Diagnostic Nano-Probe for Detection of Alzheimer Biomarker Based on SERS and MRI Dual Modalities, Poster Presentation: Varsha Karunakaran.
  • 31st Kerala Science Congress, Organized by Kerala State Council for Science, Technology and Environment at Fatima Mata National College, Kollam (Feb, 2-3rd, 2019); Exploration of New Phytochemical Entities from Hydnocarpus Wightiana Blume : Evolved as Potent Anticancer Hits inducing Mitochondria mediated Apoptosis through Cyt c Release, Oral Presentation: Arya J. S. Bimodal Fluorescence-SERS Encoded Nanococktail for the Multiplex Detection of Lung Cancer Biomarkers, Poster Presentation: Saranya Giridharan. A New Insight on Early Diagnosis of Alzheimer’s Disease Biomarkers by Label Based SERS Immunosensor, Poster Presentation: Varsha Karunakaran
  • NANOBIOTECK-3rd Annual Conference of Indian Society of Nanomedicine, Organized by Department of Biotechnology, AIIMS, New Delhi (Oct, 25-27th, 2018); Recent Advancement of Biocompatible Diagnostic Surface Enhanced Raman Scattering (SERS)-Nanoprobe for Spectroscopic Detection and Bioimaging of Human Cancer, Oral Presentation: Kaustabh Kumar Maiti; An Ultrasensitive SERS Based Non-Invasive Label Free Diagnosis of Exfoliated Cells from Cervical Pre- Cancerous Lesions by Raman Fingerprinting, Poster Presentation: Varsha Karunakaran
  • International Conference on Trends in Biochemical and Biomedical Research, Organized by Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi (Feb, 13-15th, 2018); SERS Assisted Profiling of Molecular and DNA Level Damage during Apoptosis Induced by Targeted Three in One Theranostic Nanoprobe for Metastatic Melanoma, Oral Presentation: Sujai P. T.; Exploring Hydnocarpin wightiana Blume for the Development of New Chemical Entities Towards Cancer Treatment, Oral Presentation: Arya J. S.
  • 30th Kerala Science Congress, Organized by Kerala State Council for Science, Technology and Environment at Government Brennen College, Thalassery, Kannur (Jan, 28-30th, 2018); A New Insight on Non-invasive Label Free Diagnosis of the Cervical Pre-cancers by Metabolomics and Genomics Profiling using Differential SERS Fingerprinting, Oral Presentation: Varsha Karunakaran.
  • Recent Advances in Photonics, Organized by Department of Atomic and Molecular Physics, Manipal University, Manipal ( Nov 13, 2017); Emerging Trends in  Raman Spectroscopy Towards Biology and Medicine, Invited talk: Kaustabh Kumar Maiti.
  • 6th Asian Biomaterial Congress on Innovative Biomaterials: Technologies for Life and Society, Organised by Sree Chitra Tirunal Institute for Medical Sciences & Technology , Thiruvananthapuram (Oct,  25-27th, 2017 ); Emerging Trends in  Diagnostic and Theranostic Nanoprobe for Cancer Treatment, Invited talk: Kaustabh Kumar Maiti.
  • 8th East Asia Symposium on Functional Dyes and Advanced Materials, Organised by CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram (Sep 20-22, 2017); Poster presentation: Saranya Giridharan, Ramya A.N.
  • International Conference on Emerging Trends in Chemical Sciences, Organised by Manipal Institute of Technology at Manipal University (Sep 14-16, 2017); Emerging Trends in Targeted Drug Delivery System (TDDS), Diagnostic and Theranostic Nanoprobe for Cancer Treatment, Invited talk: Kaustabh Kumar Maiti.
  • 2nd International conference on nutraceuticals and chronic diseases, Organized by IIT Guwahati at Bugmallo, Goa (Sep 1-3, 2017); Exploring Anti-cancer Potential of Hydnocarpin-Isoxazole derivatives as New Chemical Entities; Invited talk: Kaustabh Kumar Maiti.
  • 53rd Annual Convention of Chemists, Organized by Indian Chemical Society, Kolkata at Gitam university Visakhapatanam. (Dec 25-27th 2016);Exploring Anti-cancer Potential of Hydnocarpin-Isoxazole derivatives as New Chemical Entities; Poster presentation : Arya J.S , Ramya A.N and Kaustabh Kumar Maiti.
  • National Seminar on Omics & Biomarker Analysis: In disease Pathology 2.0 & Young Investigators Retreat, Organized by Department of Zoology, University of Kerala,  (Dec 19-21 st 2016) ; Recent development of Surface Enhanced Raman Scattering (SERS) nanotag for molecular level detection and bioimaging of cancer cells, Invited Talk :  Kaustabh Kumar Maiti.
  • Internatinal Conference on Advanced Materials SCICON ’16 materials for a better tomorrow; Organized by Department of Sciences, Amrita Vishwa Vidyapeetam Coimbatore (Dec 19-21 st 2016) ; Recent development on Biocompatible Theranostic Surface Enhanced Raman Scattering (SERS) nanoprobe for spectroscopic detection and bioimaging of human cancer : Invited Talk :  Kaustabh Kumar Maiti.
  • Symposium on Celebrating 25 years of Harmony with Organic Chemistry (CYHOC-2016), Organized by students of Dr. G . Vijay Nair, (Dec16-17th, 2016); Short Lecture; Exploring hydnocarpin Guanidinium appended dendron conjugate: A promising candidate for anti- Neoplastic effects in chemotherapy; Invited Talk : Kaustabh Kumar Maiti.
  • Internatinal Conference on Current Trends in Biotechnology (ICCB-2016), Organized by School of Biosciences and Technology, VIT University, Vellore in association with the Biotech Research Society , India   (Dec, 8-10th, 2016); New Insight of Surface Enhanced Raman Scattering (SERS) nanoprobe for spectroscopic detection and bioimaging of human cancer : Invited Talk :  Kaustabh Kumar Maiti.
  • 6th Internatinal Conference on Current Trends in Drug Discovery and Research (CTDDR-2016), Organized by CSIR-CDRI Lucknow (Feb, 25-28th, 2016); Cancer Cell-Specific Induction of Apoptosis By Precise Delivery of Doxorubicin using a dual targeting Dendron based transporter; Poster presentation : Jyothi B Nair, Manu M  Joseph and Kaustabh Kumar Maiti.
  • 4th International Conference on Frontiers in Nanoscience and Technology (COCHIN NANO-2016), Organized by  CUSAT,Cochin (Feb 20-23rd, 2016); New Insight of Biocompatible Surface Enhanced Raman Scattering (SERS) Nanotag for Spectroscopic Detection and Bioimaging of Human Cancer;Invited Talk :  Kaustabh Kumar Maiti.
  • 18th CRSI National Symposium in Chemistry ; Organized by Punjab University, Chandigarh, India (Feb, 5-6th, 2016); Stimuli Responsive Nanocarrier Drug Delivery System (DDS) For Targeted Delivery of Doxorubicin towards Folate Expressing Cancer Cells; Poster presentation : Ramya A. N, Sujai P. T. Manu M. Joseph and Kaustabh Kumar Maiti.
  • International Seminar on Recent Biochemical Approaches in Therapeutics : RBAT II; Organized by Kerala Univ. Department of Biochemistry, Thiruvananthapuram (December, 9-12th, 2015); Oral presentation: Manu M Joseph.
  • International Seminar on Recent Biochemical Approaches in Therapeutics : RBAT II; Organized by Kerala Univ. Department of  Biochemistry, Thiruvananthapuram (December, 9-12th, 2015); Invited Talk :Kaustabh Kumar Maiti.
  • The International Symposium on Photonics Applications and Nanomaterials; Organized by Sree Chitra Tirunal Institute for Medical Sciences & Technology , Thiruvananthapuram (Oct,  28-30th, 2015 ); A New Insight of  Squaraine Based Raman Reporters for Construction of Diagnostic SERS Nano-Probe in Cancer Screening,Poster presentation :  Nisha Narayanan, Ramya A N, Varsha Karunakaran and Kaustabh K. Maiti.
  • The International Symposium on Photonics Applications and Nanomaterials; Organized by Sree Chitra Tirunal  Institute for Medical Sciences & Technology , Thiruvananthapuram (Oct,  28-30th, 2015 ); Investigation of Tetra Phenyl Ethylene (TPE) Based Raman Reporters for Construction of SERS Nanoprobe in Prostate Cancer Detection, Poster presentation : Ramya A. N., Manu J., Saranya G., Jyothi B. N., Sujai P. T. and K. K. Maiti.
  • The Ramanbhai Foundation 7th International Symposium on Current Trends in Pharmaceutical Sciences ”Advances in New Drug Discovery & Development”; Organized by Zydus Research Centre, Ahmedabad, India (Feb, 2-4, 2015 ); An Efficient Approach on Guanidium Appended Molecular Transporter For Targeted Delivery of Doxorubicin Towards Malignant Cells: A Future Prospect in Cancer Therapy; Poster presentation : Jyothi B Nair, Santhi Maniganda, Varsha Karunakaran, Kaustabh Kumar Maiti.
  • 6th International Conference on Nano Science and Technology (ICONSAT 2014); Organized by Institute of Nano Science and Technology (INST), Mohali, Punjab ( March, 2-5, 2014); New Insight of Squaraine Based Raman Reporters for Construction of Diagnostic SERS Nano-Probe In Cancer Screening; Poster presentation: Nisha N, Jyothi B Nair, Kaustabh Kumar Maiti.
  • 2nd International Conference on Advanced Functional Materials (ICAFM 2014), Organized by CSIR-NIIST, Trivandrum (19-21 February, 2014): New Insight of Squaraine Based Raman Reporters for Construction of Diagnostic SERS Nano-Probe In Cancer Screening. Poster presentation: Nisha N, Jyothi B Nair, Kaustabh Kumar Maiti.
  • 27th International Carbohydrate Symposium (ICS27), Organized by Department of Organic Chemistry, Indian Institute of Science, Bangalore, India (12 – 17th January, 2014); Construction of Drug Delivery Vector: Sorbitol Based Carrier Conjugated with Cathepsin B Peptide Sequence targeting Towards Lysosome. Poster presentation; Santhi Maniganda, Vandana, Raghu K.G, Kaustabh Kumar Maiti.
  • National Seminar on Emerging Trends in Chemical Sciences (ETCS-2013): Organized by Department of Chemistry, University of Kerala, Kariavattom, Trivandrum (May, 29-31st, 2013;Development of Highly Sensitive Biocompatable Surface Enhanced Raman Scattering (SERS) Nanotag for Spectroscopic Detection and Bioimaging of Human Cancer); Invited Talk; Kaustabh Kumar Maiti.
  • Nano India 2013 (19-20th February, 2013) Organized by CSIR-NIIST, Trivandrum and Supported by Nano Mission, DST, New Delhi Development of Highly Sensitive Biocompatible SERS Nanotags for Spectroscopic Detection and Bioimaging of Human cancer in a Murine Xenograft Model” Poster Presentation; Kaustabh Kumar Maiti.
  • 5th Asian Conference on Colloid and Interface Sciences (ACCIS 2013): Organized by Asian Society for colloid and Surface Science (ASCASS), Department of Chemistry, University of North Bengal, Darjeeling, India. (November, 20th to 23rd, 2013); Development of Highly Sensitive Biocompatible Surface Enhanced Raman Scattering (SERS) Nanotag for Spectroscopic Detection and Bioimaging Human Cancer.Oral Presentation; Kaustabh Kumar Maiti.
  • A*STAR CHEMISTRY SYMPOSIUM, A*STAR Scientific Conference; 10th November, 2011, Biopolis, Singapore;“ Development of Biocompatible SERS Nanotag with Increased Stability for in vivo Cancer Detection”, (Invited Talk) Kaustabh Kumar Maiti, Animesh Samanta, Marc Vendrell and Young Tae Chang.
  • A*STAR CHEMISTRY SYMPOSIUM, A*STAR Scientific Conference; 1st October, 2009, Biopolis, Singapore; “Synthesis of Novel Raman Reporters and characterization of their SERS properties in a gold colloid”, Poster presentation; Kaustabh Kumar Maiti, Sung Ju Cho and Young Tae Chang.
  • 236th National Meeting and Exposition organized by American Chemical Society (ACS), Philadelphia, USA, August, 17th to 21st, 2008 Differentially innate immune detection of peptidoglycan by Toll –like receptor” Oral presentation in Carbohydrate Chemistry Division; Kaustabh K Maiti, Jinkeng Asong, Margreet Wolfert, Douglas Miller, Geert-Jan Boons.
  • 236th National Meeting and Exposition organized by American Chemical Society (ACS), Philadelphia, USA, August, 17th to 21st, 2008; “ Differential recognition of Gram-positive and –negative synthetic peptidoglycan fragments by Toll-like receptor 2” ( Poster presented in Medicinal chemistry Division;) Kaustabh K Maiti, Jinkeng Asong, Margreet Wolfert, Douglas Miller, Geert-Jan Boons.
  • The 11th Korea-Japan Joint Symposium On Drug Design and Development, May, 10-12, 2006, Jeju Island, Korea.Design and Synthetic Studies of Novel Guanidine-containing Molecular-Transporters Using Inosito dimers as Scaffold, (Poster presentation) Kaustabh K. Maiti, Ock-Youm Jeon, Woo Sirl Lee and Sung-Kee Chung.
  • XVII NATIONAL SYMPOSIUM ON ORGANIC CHEMISTRY held in honour of Professor (Mrs.) Ashima Chatterjee on the occasion of her 80th Birth Anniversary, at Science City, Kolkata, India.“1,3-dipolar cycloadditions of nitrones to stereoselective cinnamic acid piperidides”; (Poster Presentation).Kaustabh K Maiti, . Avijit Banerji, Sunanda Halder (nee Datta), T.Prange and A. Neuman.
  • International conference on chemistry and 36th annual Convention of Chemists organized by INDIAN CHEMICAL SOCIETY, (11 to16th Dec, 1999, Calcutta, India). “ Stereo-and region-selective cycloaddtions of acylic C-aryl-N-methyl nitrones (Poster presentation) Kaustabh K Maiti, . Avijit Banerji, Sunanda Halder (nee Datta), T.Prange and A. Neuman.
  • 84th Indian Science Congress, Delhi University, 3th -8th January, 1997.“ Investigations of the cycloaddition of C,N-Diarylnitrones to 1,4-disubstituted-1,3-diene compounds.” (Oral Presentation) Kaustabh Kumar Maiti, Avijit Banerji, Sunanda Halder (nee Datta), T. Prange and A. Neuman.

Webinar presentations:

  • International conference on Materials & Millennium (MatCon 2021) (March 15-19th, 2021), Dept. of Applied Chemistry, Cochin University of Science & Technology, Kochi, India. “Recent Advances in cancer Nanotechnology”.
  • Webinar Series 2020, Advances in Biological Sciences (August 21st 2020) , Dept. of Botany, University of Kerala, Thiruvananthapuran, India, ” Molecular Diagnostic Platforms Through CHemistry, Biology and Nanotechnology”.
Publications

2021

  • Elucidating Raman Image-Guided Differential Recognition of Clinically Confirmed Grades of Cervical Exfoliated Cells by Dual Biomarker-Appended SERS-Tag; Varsha Karunakaran, Valliamma N. Saritha, Adukkadan N. Ramya, Vishnu Priya Murali, Kozhiparambil G. Raghu, Kunjuraman Sujathan,* and Kaustabh Kumar Maiti*, Anal. Chem. DOI: 10.1021/acs.analchem.1c01607.
  • DNA Condensation Triggered by the Synergistic Self-Assembly of Tetraphenylethylene-Viologen Aggregates and CT-DNA; Sajena Kanangat Saraswathi, Varsha Karunakaran, Kaustabh Kumar Maiti and Joshy Joseph*, Frontiers in Chemistry, DOI: 10.3389/fchem.2021.716771.
  • Mirabijalones S-W, rotenoids from rhizomes of white Mirabilis jalapa Linn. and their cell proliferative studies; P. Sharathna, V. Alisha, P. Sasikumar, Ajesh Vijayan, F. Ayisha, I.G. Shibi, V.V. Sivan, Kaustabh Kumar Maiti, Ravi S. Lankalapalli, K.V. Radhakrishnan*, Phytochemistry Letters, 44 (2021) 178–184.
  • Phthalimide conjugation turns the AIE-active tetraphenylethylene unit non-emissive: its use in turn-on sensing of hydrazine in solution and the solid- and vapour-phase; Sharanabasava D. Hiremath, Ram U. Gawas, Dharmendra Das, Viraj G. Naik, Akhil A. Bhosle, Vishnu Priya Murali, Kaustabh Kumar Maiti, Raghunath Achary, Mainak Banerjee* and Amrita Chatterjee* RSC Adv., 2021, 11, 21269–21278.
  • Nanohybrids of Magnetically Intercalated Optical Metamaterials for Magnetic Resonance/Raman Imaging and In Situ Chemodynamic/ Photothermal Therapy; Kunnumpurathu Jibin, Marina Victor, Giridharan Saranya, Hema Santhakumar, VishnupriyaMurali, KaustabhK.Maiti, and Ramapurath S. Jayasree* ACS Appl. Bio Mater. 2021, 4, 7, 5742–5752.
  • Antiproliferative labdane diterpenes from the rhizomes of Hedychium flavescens Carey ex Roscoe; Santhi Subramanyan, Selvakumar Deepika, Anjitha Ajith, Anuja Joseph Gracy, Mathew Dan, Kaustabh Kumar Maiti1, Ramavarma Luxmi Varma, Kokkuvayil Vasu Radhakrishnan*  Chem Biol Drug Des. 2021;00:1–6.
  • Elucidating Gold-MnO2 Core-Shell Nanoenvelope for Real Time SERS-Guided Photothermal Therapy on Pancreatic Cancer Cells; Palasseri T. Sujai, Shanmughan Shamjith, Manu M. Joseph, and Kaustabh Kumar Maiti* ACS Appl. Bio Mater. 2021, DOI: 10.1021/acsabm.1c0024
  • Raman Imaging: An Impending approach towards cancer diagnosise; Adukkadan N Ramya, Jayadev S Arya, Murali Madhukrishnan, Shanmughan Shamjith, Murukan S Vidyalakshmi, Kaustabh Kumar Maiti* Chem. An Asian Journal, 2021, 16, 409 –422.
  • Amphiphilic fluorescent probe self-encored in plasma to detect pH fluctuation in cancer cell membrane; Arup Podder,   Manu M Joseph,   Shayeri Biswas,   Sanjib Samanta,   Kaustabh K. Maiti*  and  Sankarprasad Bhuniya * Chem. Commun., 2021,57, 607-610.
  • A single benzene fluorescent probe for efficient formaldehyde sensing in living cells using glutathione as an amplifier; Anal Jana, Manu M.Joseph, Subrata Munan, Shamna K., Kaustabh Kumar Maiti* and Animesh Samanta;* Journal of photochemistry and photobiology B: Biology, 2021, 214, 112091.

2020

  • Highly selective chemosensor for reactive carbonyl species based on simple 1,8-diaminonaphthalene; Anal Jana, Manu M. Joseph, Subrata Munan, Kaustabh Kumar Maiti*, Animesh Samanta;* Journal of photochemistry and photobiology B: Biology, 2020, 213, 112076.
  • Biocompatible fluorescent probe for detecting mitochondrial alkaline phosphatase activity in live cells; Sabina Khatun, Shayeri Biswas, Arun Kumar Mahanta, Manu M. Joseph,Murukan S. Vidyalekshmi, Arup Podder, Pralay Maiti, Kaustabh Kumar Maiti, Sankarprasad Bhuniyaa*; Journal of Photochemistry & Photobiology, B: Biology, 2020, 212, 11204.
  • Elucidating a Thermo-responsive Multimodal Photo-Chemotherapeutic Nano-delivery Vehicle to Overcome the Barriers of Doxorubicin Therapy ; Jyothi B Nair, Manu M Joseph*, Jayadev S Arya, Padincharapad Sreedevi, Palasseri T Sujai, and Kaustabh Kumar Maiti*; ACS Applied Materials and Interfaces, 2020, 12, 39, 43365–43379.
  • NADH-Activated Dual Channel Fluorescent Probe for Multicolor Labeling of Live Cells and Tumor Mimic Spheroid; Arup Podder, Vishnu Priya Murali, Selvakumar Deepika, Avinash Dhamija, Shayeri Biswas, Kaustabh Kumar Maiti*, and Sankarprasad Bhuniya*; Analytical Chemistry , 2020, 92, 12356-12362.
  • Tracking the Foot-prints of Paclitaxel Delivery and Mechanistic Action via SERS Trajectory in Glioblastoma Cells; Jyothi B Nair, Saswat Mohapatra, Manu M Joseph, Santhi Maniganda, Varsha Gupta, Surajit Ghosh, and Kaustabh Kumar Maiti* ACS Biomater. Sci. Eng., 2020, 6, 9, 5254–5263.
  • Diagnostic Spectro-cytology revealing differential recognition of cervical Cancer lesions by label-free surface enhanced Raman fingerprints and Chemomssetrics; Varsha Karunakaran, Valliamma N. Saritha, Manu M.Joseph, Jyothi B. Nair, Giridharan Saranya, Kozhiparambil G. Raghu, Kunjuraman Sujathan*, Krishnan Nair S. Kumar*, Kaustabh K. Maiti* Nanomedicine: Nanotechnology, Biology and Medicine, 2020, 29,  102276.
  • Targeted Theranostic Nano Vehicle Endorsed with Self-Destruction and Immunostimulatory Features to Circumvent Drug Resistance and Wipe-Out Tumor Reinitiating Cancer Stem Cells; Manu M. Joseph,* Adukkadan N. Ramya, Vineeth M. Vijayan, Jyothi B. Nair, Blossom T. Bastian, Raveendran K. Pillai, Sreelekha T. Therakathinal,* and Kaustabh K. Maiti* Small, 2020, 16, 2003309.
  • A new pentacyclic pyrylium fluorescent probe that responds to pH imbalance during apoptosis; Sandip Chakraborty, Manu M Joseph, Sunil Varughese, Samrat Ghosh, Kaustabh Maiti, Animesh Samanta* and Ayyappanpillai Ajayaghosh*; Chem. Sci., 2020, 11, 12695–12700.
  • Self-assembled drug loaded glycosyl-protein metal nanoconstruct: Detailed synthetic procedure and therapeutic effect in solid tumor treatment; B.S. Unnikrishnana, S. Mayaa, G.U. Preethia, K.S. Anusreea, P.L. Reshmaa, M.G. Archanaa, Maiti Kumar Kaustabh, T.T. Sreelekhaa*; Colloids and Surfaces B: Biointerfaces 193 (2020) 111082.
  • Reduced Graphene Oxide-Thioguanine Composites for the Selective Detection of Inorganic and Organic Mercury in Aqueous Media; Sharanabasava D. Hiremath, Kaustabh Kumar Maiti, Narendra Nath Ghosh, Mainak Banerjee*, Amrita Chatterjee*; ACS Applied Nano Materials  2020, 3, 3, 3071-3079.
  • Optically Controlled Hybrid Metamaterial of Plasmonic Spiky Gold Inbuilt Graphene Sheets for Bimodal Imaging Guided Multimodal Therapy; Kunnumpurathu Jibin, Jayaram S. Prasad, Giridharan Saranya, Sachin J. Shenoy, Kaustabh K. Maiti, Ramapurath S. Jayasree*; Biomater. Sci., 2020, 8, 3381-3391.
  • Surface charge modulates the internalization vs  penetration of gold nanoparticles: comprehensive scrutiny on monolayer cancer cells, multicellular spheroids and solid tumors by SERS modality; Palasseri T. Sujai, Manu M. Joseph,* Giridharan Saranya, Jyothi B. Nair, Vishnu Priya Murali and Kaustabh Kumar Maiti*; Nanoscale, 2020, 12, 6971–6975.
  • Biogenic Ag Nanoparticles of Neem Extract; its Structural Evaluation and Antimicrobial Effects against Pseudomonas nitroreducens and Aspergillus unguis – NII 08123; Sarah B. Ulaeto, Gincy Marina Mathew, Jerin K Pancrecious, Jyothi B Nair, Thazhavilai Ponnu Devaraj Rajan, Kaustabh Kumar Maiti, and B.C. Pai, ACS Biomater. Sci. Eng. 2020, 6, 1, 235-245. (Impact Factor: 4.74)

2019

  • Galactoxyloglucan-Modified Gold Nanocarrier of Doxorubicin for Treating Drug-Resistant Brain Tumors; Remya Komeri, Maya S, B. S. Unnikrishnan, J. Sreekutty, Preethi GU, Kaustabh Kumar Maiti, and Therakathinal T. Sreelekha* ACS Appl. Nano Mater. , 2019, 2, 6287-6299.
  • Exploring Mitochondria Mediated Intrinsic Apoptosis by New Phytochemical Entities: An Explicit Observation of Cytochrome c Dynamics on Lung and Melanoma Cancer Cells-; Jayadev S Arya, Manu M Joseph*, Daisy Sherin, Jyothi B Nair, Thanathu Krishnan Manojkumar*, and Kaustabh Kumar Maiti* J. Med. Chem., 2019, 62, 8311-8329.
  • NADH- Induced “kick-on” Fluorescent Probe Validates Cross talk with Redox Regulator GSH; Mrinmoy Maiti,  Vishnu Priya Murali,  Selvakumar Deepika,  Arup Podder,  Kaustabh Kumar Maiti,*and Sankarprasad Bhuniya* Sensors & Actuators: B. Chemical, 2019, 299, 126964.
  • Curcuma raktakanda Induces Apoptosis and Suppresses Migration in Cancer Cells: Role of Reactive Oxygen Species; Shruti Mishra, Sumit Singh Verma, Vipin Rai, Nikee Awasthee, Jayadev S. Arya, Kaustabh Kumar Maiti, and Subash C. Gupta* Biomolecules, 2019, 9, 159.
  • Bimodal Detection of Carbon Dioxide Using Fluorescent Molecular Aggregates; Rakesh K. Mishra, Samiyappan Vijayakumar, Arindam Mal, Varsha Karunakaran, Jith C. Janardhanan, Kaustabh Kumar Maiti, Vakayil K. Praveen and Ayyappanpillai Ajayaghosh* Chem. Commun., 2019, 55, 6046-6049.
  • Endogenous H2S-Assisted Cancer-Cell-Specific Activation of Theranostics with Emission Readout; Kondapa Naidu Bobba, Giridharan Saranya, Palasseri T. Sujai, Manu M. Joseph, Nithya Velusamy, Arup Podder, Kaustabh Kumar Maiti*, and Sankarprasad Bhuniya* ACS Applied Biomaterials, 2019, 2, 1322-1330.
  • Biogenic Cluster-Encased Gold Nanorods as a Targeted Three-in-One Theranostic Nanoenvelope for SERS-Guided Photochemotherapy against Metastatic Melanoma; Palasseri T. Sujai, Manu M. Joseph*, Varsha Karunakaran, Giridharan Saranya, Ramya N. Adukkadan, Shanmughan Shamjith, Reshmi Thomas, Jyothi B. Nair, Rotti Srinivasamurthy Swathi, and Kaustabh Kumar Maiti* ACS Applied Biomaterials, 2019, 2 (1), pp 588–600.

2018

  • Enzyme-Driven Switchable Fluorescence-SERS Diagnostic Nanococktail for the Multiplex Detection of Lung Cancer Biomarkers; Giridharan Saranya,Manu M. Joseph, Varsha Karunakaran, Jyothi B. Nair, Valliamma N. Saritha, Vamadevan S. Veena, Kunjuraman Sujathan*, Ayyappanpillai Ajayaghosh*, and Kaustabh K. Maiti*, ACS Applied Materials and Interfaces, 2018, 10 (45), pp 38807–38818.
  • Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines; P. R. Nitha, Manu M. Joseph, Greeshma Gopalan, Kaustabh Kumar Maiti,* K. V. Radhakrishnan* and  Parthasarathi Das*, Organic & Biomolecular Chemistry, 2018, 16, 6430.
  • Experimental and DFT studies for substituent effects on cycloadditions of C,N-disubstituted nitrones to cinnamoyl piperidine; Sutapa Mandal, Kaustabh K Maiti, Avijit Banerji, Thierry Prangé, Alain Neuman & Nivedita Acharjee*, Indian Journal of Chemistry, 2018, 57B, 108-119.
  • Exploring the margins of SERS in practical domain: An emerging diagnostic modality for modern biomedical applications; Manu M. Joseph , Nisha Narayanan, Jyothi B. Nair, Varsha Karunakaran, Adukkadan N. Ramya, Palasseri T. Sujai , Giridharan Saranya, Jayadev S. Arya, Vineeth M. Vijayan and Kaustabh Kumar Maiti*, Biomaterials, 2018, 140-181.
  • Magnetic properties of biocompatible CoFe2O4 nanoparticles using a facile synthesis; Annrose Sunny, Aneesh Kumar K.S., Varsha Karunakaran, Aathira M., Geeta R. Mutta, Kaustabh K. Maiti, V. Raghavendra Reddy, M. Vasundhara*, Nano-Structures & Nano-Objects, 2018, 69–76.
  • Calix[4]arene Based Redox Sensitive Molecular Probe for SERS Guided Recognition of Labile Iron Pool in Tumor Cells; Padincharapad Sreedevi, Jyothi B. Nair, Preethalayam Preethanuj, Benadicta S. Jeeja, Cherumuttathu H. Suresh*, Kaustabh Kumar Maiti*, and Ramavarma Luxmi Varma*, Anal. Chem., 2018, 90 (12), 7148–7153.
  • pH-Controlled Nanoparticles Formation and Tracking of Lysosomal Zinc Ions in Cancer Cells by Fluorescent Carbazole–Bipyridine Conjugates; Karivachery V. Sudheesh, Manu M. Joseph, Divya S. Philips, Animesh Samanta, Kaustabh Kumar Maiti, and Ayappanpillai Ajayaghosh*, ChemistrySelect, 2018, 3, 2416 – 2422.
  • SERS-Active Multi-Channel Fluorescent Probe for NO: Guide to Discriminate Intracellular Biothiols; Kondapa Naidu Bobba, Giridharan Saranya, Susan M. Alex, Nithya Velusamy, Kaustabh Kumar Maiti*, and Sankarprasad Bhuniya*, Sensors and Actuators B, 2018, 260, 165-173.
  • Ultrasensitive NIR-SERRS Probes with Multiplexed Ratiometric Quantification for In Vivo Antibody Leads Validation; Homan Kang, Sinyoung Jeong, Ahla Jo, Hyejin Chang, Jin-Kyoung Yang, Cheolhwan Jeong, San Kyeong, Youn Woo Lee, Animesh Samanta, Kaustabh Kumar Maiti, Myeong Geun Cha, Taek-Keun Kim, Sukmook Lee, Bong-Hyun Jun, Young-Tae Chang, Junho Chung, Ho-Young Lee,* Dae Hong Jeong,* and Yoon-Sik Lee*, Adv. Healthcare Mater., 2018, 7, 1700870.

2017

  • Plasmonically Enhanced Galactoxyloglucan Endowed Gold Nanoparticles Exposed Tumor Targeting Biodistribution Envisaged in a Surface-Enhanced Raman Scattering Platform; Manu M. Joseph, Jyothi B. Nair, Kaustabh K. Maiti*, Sreelekha Therakathinal T*, Biomacromolecules, 2017, 18 , 4041–4053.
  • Self-calibrated Fluorescent Probe Resembled as an Indicator of the Lysosomal Phosphatase Pertaining to the Cancer Cells; Arun Podder, Susan M. Alex, Mrinmoy Maiti, Kaustabh K. Maiti*, Sankarprasad Bhuniya*, J Photochem Photobiol B., 2017, 177, 105-111.
  • Unveiling NIR Aza-Boron-Dipyrromethene (BODIPY) Dyes as Raman Probes: Surface-Enhanced Raman Scattering (SERS)-Guided Selective Detection and Imaging of Human Cancer Cells.; Adarsh N, Ramya A N, Kaustabh K. Maiti* and Ramaiah D.* ,Chem. Eur. J., 2017,  23, 14286.
  • A Ratiometric Near-Infrared Fluorogen for the Real Time Visualization of Intracellular Redox Status during Apoptosis; Giridharan Saranya, Palapuravan Anees, Manu M. Joseph,  Kaustabh K. Maiti,* and Ayyappanpillai Ajayaghosh*,Chem. Eur. J., 2017, 23, 7191 – 7195.
  • Emergence of Gold-Mesoporous Silica Hybrid Nano-Theranostic: Dox-Encoded, Folate Targeted Chemotherapy with Modulation of SERS Fingerprinting for Apoptosis Toward Tumor Eradication;Adukkadan N. Ramya, Manu M. Joseph,* Santhi Maniganda, Varsha Karunakaran, Sreelekha T.T,* and Kaustabh Kumar Maiti*,Small, 2017, 13, 1700819.
  • Exploration of Biogenic Nano-chemobiotics Fabricated by Silver Nanoparticle and Galactoxyloglucan with an Efficient Biodistribution in Solid Tumor Investigated by SERS Fingerprinting; Manu M. Joseph, Jyothi B. Nair, Ramya N. Adukkadan, Neethu Hari, Raveendran K. Pillai,  Ananthakrishnan J. Nair, Kaustabh Kumar Maiti,* and Sreelekha Therakathinal T, ACS Appl. Mater. Interfaces, 2017, 9, 19578-19590.
  • Single cell lipid profiling of Scenedesmus quadricauda CASA-CC202 under nitrogen starved condition by surface enhanced Raman scattering (SERS) fingerprinting; A. N. Ramya , P.S. Ambily , B. S. Sujitha, Muthu Arumugam, Kaustabh Kumar Maiti*,Algal Research, 2017, 25, 200-206.

2016

  • New Insight into a Cancer Theranostic Probe: Efficient Cell-Specific Delivery of SN-38 Guided by Biotinylated Poly(vinyl alcohol); Debabrata Dutta,Susan M. Alex, Kondapa Naidu Bobba, Kaustabh Kumar Maiti* and Sankarprasad Bhuniya*,ACS Appl. Mater. Interfaces., 2016, 8, 33430-33438.
  • TEMPO-Oxidized Nanocellulose Fiber-Directed Stable Aqueous Suspension of Plasmonic Flower-like Silver Nanoconstructs for Ultra-Trace Detection of Analytes; Kallayi Nabeela, Reny Thankam Thomas, Jyothi B. Nair,Kaustabh Kumar Maiti, Krishna Gopa Kumar Warrier, and Saju Pillai, *, ACS Appl. Mater. Interfaces., 2016, 8 (43), pp 29242–29251.
  • Guanidinium rich dendron-appended hydnocarpin exhibits superior anti-neoplastic effects through caspase mediated apoptosis; Bincy Mariyam Mathai, Manu M. Joseph, Santhi Maniganda, Jyothi B. Nair, J. S. Arya, Varsha Karunakaran, K. V. Radhakrishnan* and Kaustabh Kumar Maiti *, RSC Adv., 2016, 6, 52772-52780.
  • Investigation of apoptotic events at molecular level induced by SERS guided targeted theranostic nanoprobe; Nisha Narayanan, Lakshmi V. Nair, Varsha Karunakaran, Manu M. Joseph, Jyothi B. Nair, Ramya A. N, Ramapurath S. Jayasree* and Kaustabh Kumar Maiti*, Nanoscale., 2016, 8, 11392-1139.
  • New Insight of Tetraphenylethylene-based Raman Signatures for Targeted SERS Nanoprobe Construction Toward Prostate Cancer Cell Detection;Adukkadan N. Ramya, Manu M. Joseph, Jyothi B. Nair, Varsha Karunakaran,Nisha Narayanan, and Kaustabh Kumar Maiti*, ACS Appl. Mater. Interfaces., 2016, 8, 10220-10225.
  • A Dual-Targeting Octaguanidine–Doxorubicin Conjugate Transporter for Inducing Caspase-Mediated Apoptosis  on  Folate-Expressing Cancer Cells ; Jyothi B. Nair, Manu M. Joseph,  Saswat Mohapatra, M. Safeera, Surajit    Ghosh*, T. T. Sreelekha*, and Kaustabh Kumar Maiti*, ChemMedChem., 2016, 11,702-712.
  • Aggregation induced Raman scattering of squaraine dye: Implementation in diagnosis of cervical cancer dysplasia by SERS imaging ; Nisha Narayanan, Varsha Karunakaran, Willi Paul, Karunakaran Venugopal, K. Sujathan, Kaustabh Kumar Maiti*, Biosensors and Bioelectronics., 2015,70,145-152.
  • Novel lysosome targeted molecular transporter built on a guanidinium-poly-(propylene imine) hybrid Dendron for efficient delivery of doxorubicin into cancer cells; Jyothi B Naiir, Saswat Mohapatra, Surajit Ghosh, Kaustabh K. Maiti*,Chem. Commun., 2015, 51, 2403-2406.
  • New insight of squaraine-based biocompatible surface-enhanced Raman scattering nanotag for cancer-cell imaging; AN Ramya, Animesh Samanta2, N Nisha, Young-Tae Chang & Kaustabh Kumar Maiti* Nanomedicine., 2015;10(4), 561–571.

2014

  • A Lysosome – Targeted Drug Delivery System based on Sorbitol Backbone towards Efficient Cancer     Therapy; Santhi Maniganda,Vandana Sankar,Jyothi B Nair, Raghu K G, Kaustabh K Maiti*, Org. Biomol. Chem, 2014, 12, 6564-6569.

2013

  • Multiplexing SERS nanotags for the imaging of differentiated mouse embryonic stem cells (mESC) and detection of teratoma in vivo Samanta, A.; Das, R.; Park, S. J.; Maiti, K. K.; Chang, Y. T.* Am. J. Nucl. Med. Mol. Imaging, 2014, 4, 114-124.
  • Surface-enhanced Raman scattering in cancer detection and imaging M. Vendrell*, K. K. Maiti*, K. Dhaliwal, Y-T Chang, Trends in Biotechnolgy, 2013, 31, 249-254.

Before joining CSIR-NIIST

  • Multiplex Targeted in vivo Cancer Detection Using Sensitive Near-Infrared SERS Nanotags; Kaustabh Kumar Maiti, Dinish U. S, Animesh Samanta, Marc Vendrell, Kiat-Seng Soh, Sung Jin Park, Malini Olivo Young-Tae Chang* Nano Today, 2012, 7, 85-93.
  • Pluronic Triblock Copolymer Functionalized Gold Nanorods as Biocompatible Localized Plasmon Resonance Enhanced Scattering Probes for Dark-Field Imaging of Cancer Cells;Douglas Goh, Tianxun Gong, U. S. Dinish,* Kaustabh Kumar Maiti, Fu Chit Yaw, Ken-Tye Yong*, Malini Olivo* Plasmonics, 2012, 7, 595-601.
  • Preparation of Blood-brain barrier-permeable Paclitaxel-carrier Conjugate and its Chemotherapeutic Activity in the Mouse Glioblastoma Model; Juyoun Jin, Woo Sirl Lee, Kyeung Min Joo, Kaustabh K. Maiti, Goutam Biswas, Wanil Kim, Kyong-Tai Kim, Se Jeong Lee, Kang-Ho Kim, Do-Hyun Nam,* and Sung-Kee Chung* Med. Chem. Commun., 2011, 2, 270-273.
  • Multiplex Cancer Cell Detection by SERS Nanotags with Cyanine and Triphenylmethine Raman Reporters;Kaustabh Kumar Maiti, Animesh Samanta, Marc Vendrell, Kiat-Seng Soh, Malini Olivo, Young-Tae Chang* Chemical Communications, 2011, 47, 3514-3516.
  • Development of Ultrasensitive Near-Infrared Raman Reporters for SERS-based in vivo Cancer Detection;Animesh Samanta, Kaustabh Kumar Maiti, Kiat-Seng Soh, Xiaojun Liao, Seong-Wook Yun, Ramaswamy Bhuvaneswari, Marc Vendrell, Hyori Kim, Shashi Rautela, Malini Olivo, Junho Chung, Young-Tae Chang*. Angew .Chem. Int. Ed., 2011, 50, 6089-6092.
  • Cellular Uptake Properties of the Complex Derived from Quantum Dots and G8 Molecular Transporters; JungKyun Im, Kaustabh K Maiti, Wanil Kim, Kyong-Tai Kim, Sung-Kee Chung* Bull. Korean Chem. Soc., 2011, 32(4), 1282-1292.
  • Bioimaging: Raman probes for cancer diagnostics; A. Samanta, K. K. Maiti, M. Vendrell, Y. T. Chang A*STAR Resaerch (Highlights), published online on 17th August, 2011.
  • Development of Biocompatible SERS Nanotag with Increased Stability by Chemisorption of Reporter Molecule for in vivo Cancer detection; Kaustabh Kumar Maiti, Dinish U.S., Chit Yaw Fu, Jae-Jung Lee, Kiat-Seng Soh, Seong-Wook Yun, Ramaswamy Bhuvaneswari, Malini Olivo* , Young-Tae Chang* Biosensors and Bioelectronics, 2010, 26(2), 398-403.
  • Rapid synthesis of nanoscale reporter tags offers a promising alternative to fluorescent labeling; K.K. Maiti, R. Bhuvaneswari, Y. T. Chang A*STAR Research (Highlights), published online on 26th May, 2010.
  • Combinatorial Synthesis of Triphenylmethine Library and Their Application in the Development of Surface Enhanced Raman Scattering (SERS) Probes; Sung Ju Cho, Young-Hoon Ahn, Kaustabh Kumar Maiti, Dinish U. S., Chit Yaw Fu, Praveen Thoniyot1, Malini Olivo1,3,4* Young-Tae Chang1,5* Chemical Communications, 2010, 46(5), 722-724.
  • Chemical Synthesis and Proinflamatory Responses of Monophosphoryl Lipid A Adjuvant Candidates; Kaustabh K Maiti, Michael De Castro, Matthew Foote, Margreet Wolfert and Geert-Jan Boons* European Journal of Organic Chemistry, 2010, 80-91.
  • Novel Lipidated Sorbitol-based Molecular Transporters for Non-viral Gene Delivery; Tomoko Higashi, Ikramy A. Khalil, Kaustabh K. Maiti, Woo Sirl Lee, Hidetaka Akita, Hideyoshi Harashima, and Sung-Kee Chung* Journal of Controlled Release, 2009, 136(2), 140-147.
  • Toll-like receptor 2 can differentially recognize peptidoglycan fragments derived from Gram-positive and -negative bectria; Jinkeng Asong, Margreet Wolfert, Kaustabh K Maiti, Douglas Miller and Geert-Jan Boons* Journal of Biological Chemistry, 2009, 284(13), 8643-8653.
  • Recent Advances in Cell-penetrating, Non-peptide Molecular Carriers; S.-K.Chung*, Kaustabh K Maiti and Woo Sirl Lee International Journal of Pharmaceutics, 2008, 354, 16-22.
  • Novel Guanidine-containing Molecular Transporters: Sorbitol-based Transporters Show High Intracellular Selectivity toward Mitochondria; Kaustabh K. Maiti, Woo Sirl Lee, Toshihide Takeuchi, Catherine Watkins, Marjan Fretz, Dong-Chan Kim, Shiroh Futaki, Arwyn Jones, Kyong-Tai Kim and Sung-Kee Chung* Angew .Chem. Int. Ed., 2007, 46, 5880-5884.
  • Design, Synthesis, and delivery properties of Novel Guanidine containing Molecular Transporters built on Dimeric Inositol Scaffolds; Kaustabh K. Maiti, Ock-Youm Jeon, Woo Sirl Lee, Sung-Kee Chung*, Chem. Eur. J. 2007, 13, 762-775.
  • Design, Synthesis and Membrane-Translocation studies of Inositol-based Transporters; Kaustabh K. Maiti, Ock-Youm Jeon, Woo Sirl Lee, Dong-Chan Kim, Kyong-Tai Kim, Toshihide Takeuchi, Shiroh Futaki and Sung-Kee Chung*, Angew .Chem. Int. Ed., 2006, 45, 2709-2712.
  • 1,3-Dipolar cycloadditions; Part IV. Structure and Conformation of cycloadducts from Reaction of C-Aryl-N-phenylnitrones to substituted Cinnamic acid amides. Conformation of Cycloadducts from Reaction of; A. Banerji, Kaustabh K Maiti, S. Halder (nee Datta), c. Mukhopadhyay, J. Banerji, T. Prange and A. Nuuman, Monatshefte Chemie. 2000, 131, 901-911.
  • 1,3-Dipolar cycloadditions; Part III – Cycloaddition of C,N-diarylnitrones to N-cinnamoyl Piperidines; A. Banerji, S. Halder (nee Datta), Kaustabh K Maiti, S. Basu(nee Sinha), T.Prange and A. Neuman. Ind. J. Chem., Section B, 1998, 37B, 105-119.
  • Metal reagents in Organic Reactions. Part-VI. Oxidations of Indoles with Thalium (III) acetate; A.Banerji, R. Ray, S. Pal, D. Banerji and Kaustabh K Maiti J. Indian chem. Soc., 1998, 75, 698-704.
Academic Qualification
  • PhD : Synthetic organic chemistry, University of Calcutta, India, 2000
  • M.Sc : Organic Chemistry, University of Calcutta, India, 1993
  • B.Sc. (Honours): Chemistry, University of Calcutta, India, 1991
Research Interest

Research interests in my laboratory consisted at the interface between chemistry, biology and nano science. Our focus on development of Targeted Drug-Delivery System (TDDS) based on synthetic or nanocarrier for target specific delivery of small molecular drugs, proteins, nucleic acids, genes. Secondly, our interest on nano-bio-science area to develop functionalized nano-particle probes which acts as a highly sensitive diagnostic tool on surface-enhanced Raman scattering (SERS) platform for non-invasive detection of various human cancer and other diseases viz., Alzheimer. We are aiming to construct different functionalized theranostic nanoparticle probes with SERS and fluorescence based diagnosis simultaneous with PDT and PTT as therapy. We are also interested in designing, synthesizing and studying biologically active molecules, which include small molecules and natural products, peptides, glycol-peptides, antigenic-oligosaccharides and find out their role, mode of recognition in biological system. Our long term research goals are to develop unique drug-delivery system as a potential carrier of non bioavailable drugs, novel diagnostic probes for cancer screening and to processes for their commercialization.

Current research interest:

  • Targeted Drug Delivery System Development (TDDS) : Both synthetic and nano-carrier scaffold for localized therapy, sustained / controlled release.
    • Multimodal Cancer therapy : Chemo-photo ; Chemo-immuno;
    • Combined therapy on diabetic retinopathy by ocular / intravitreal pathway
  • Diagnostic Nanoparticle probes : SERS-tags for Label-free / SERS-labelled / SERS -kit.
    • Ultrasensitive detection and imaging of human cancer viz., cervical, breast, lung, thyroid, prostate
    • Detection of infectious diseases : Dengue (identification of specific viral strains)
    • Detection & quantification of lipid bodies in algaes involved in biomass production
    • Early detection and monitoring of neurodegenerative disorders : amyloid plaques and related proteins in Alzheimer’s and Parkinson Diseases
  • Multimodal theranostic nano-probes based on SERS fluorescence, MRI, as diagnostic modalities and PDT, PTT and Chemo and immunotherapy.
  • Synthetic modification of bioactive natural products isolated from plants : New Phytochemical Entities (NPCEs) as advanced Hits / lead molecules towards anti-cancer, anti-diabetic potential.
Projects

Ongoing Projects

  • Project title: Development of a sandwich model magnetic capture system for the detection of pancreatic cancer biomarkers in serum by SERS based immune assay;  Principal Investigator : Dr.Vishnu Priya Murali & Project Mentor : Dr. Kaustabh Kumar Maiti
    Funding Agency : DHR-ICMR ; 44.85 Lakhs ( 3 years)
    Duration : November, 2021 - October, 2024
  • Project title: Diagnostic Evaluation of a SERS-Nanoprobe Based Immunosensor for Early Detection of Alzheimer’s Disease Biomarkers from Blood
    Funding Agency: ICMR ( 52 Lakhs for 1st Year)
    Duration : March, 2022 to March 2025
  • Project title: Technology for the early detection of cancer from blood sample using SERS (Surface Enhanced Raman Spectroscopy) and artificial intelligence- A novel technique
    Funding Agency : CSR ( 74 Lakhs)
    Duration : October, 2022 to October, 2023

Completed Projects

NON-CSIR Project

  • Project title: Design A Smart Drug-Delivery System Using Activatable Cell- Penetrating Peptides and Scaffold Based Non-peptide Carriers For Targeting Human Cancer - Principal Investigator
    Funding agency: DST (SERB) : 27 Lakhs
    Duration : June 2013 - May, 2016
  • Project title: Gold Nanorod Based Targeted Nanoprobe For Cancer Theranostics: Diagnosis By Surface Enhanced Raman Scattering (Sers) And Fluorescence Imaging And Therapy By PDT and PTT - Principal Investigator
    Funding Agency:  DBT; 84.224 Lakhs (3 years)
    Duration : March 2016 - Feb 2019
  • Project title: Development Of Multiplexing Detection Platform Of Breast Cancer Biomarkers By Non-Invasive Surface Enhanced Raman Scattering (Sers) Nanoprobe - Principal Investigator
    Funding Agency: DST Nano Mission, 37.2 Lakhs (3 year)
    Duration : August 2017 - Dec 2020
  • Project title: Biocompatible Combined Polymer-Polysaccharide Core-shell VEGF-Targeted Nano-Carrier For Sustained Intraocular Pharmacotherapy Towards Diabetic Retinopathy - Principal Investigator
    Funding Agency: DBT, 51.23 Lakhs (3 year)
    Duration : September 2018 - August 2021
  • Project title: Engineering intelligent theranostic nanocarrier for targeted therapy and diagnosis of cancer - Principal Investigator from NIIST
    Funding Agency: DST, SERB, 16.6 Lakhs (3 year)
    Duration : August 2018 - July 2021
  • Project title: Nanostructured Surfaces for Developing SERS Sensing Platform - Co-Principal   Investigator
    Funding Agency: DBT 71.5 Lakhs (3 year)
    Duration : September 2018 - August 2021

CSIR Network Projects: 12th FYP ( March, 2012 to March, 2017)

  • Molecules To Materials To Devices (M2D)
    Lab co-ordinator from CSIR-NIIST
    Budget: 1933 Lakhs (NIIST)
    Duration : March 2012 - March 2017
    Major Achievement:  Probes for SERS based detection of cervical cancer (CSIR-NIIST; TRL 4) - These nanoprobes are being validated in clinical samples through active collaboration with Regional Cancer Centre (RCC), Trivandrum (TLR 4) - Project Leader
  • Nanomaterials: Application And Impact On Safety, Health And Environment (NanoSHE)
    Nodal Scientist from CSIR-NIIST
    Budget: 116 Lakhs
    Major Achievement: Gold Nanorod based Theranostic Nanoprobe for Photothermal Chemotherapy to MMP2 expressed cancer  tumors : (TRL3) - Nodal officer from NIIST
  • Natural Products As Affordable Healthcare Agents (NaPaHa)
    Participating Scientist from CSIR-NIIST
    Budget: 500 Lakhs
    Major Achievement: Isolation Of Anticancer Agent From Hydnocarpus Wightiana Blume.  and Its Semi Synthetic Modifications For Enhanced Anticancer Activity – Participating Scientist from NIIST

CSIR Mission Mode Project

  • Nanobiosensors and Microfluodics for Healthcare, Development of SERS-Nanoprobe for Multiplexing Diagnosis of Breast and Lung Cancer Biomarkers in Tumor Tissue Samples By Raman Fingerprint
    Duration : March 2018 - February 2020
    Project Leader from NIIST
    Budget: 749 Lakhs (For CSIR-NIIST)

CSIR FTT Project

  • Development of Cellular Sensors: Biocompatible fluorescent molecules for sensing and cellular imaging of pH, Zn2+ and reactive oxygen species
    Co-Principal Investigator / Budget : 75 Lakhs
    Duration : Aug 2018 - March 2020
  • Customized Portable Raman spectrophotometric device for multiplex detection of breast cancer biomarkers
    Co-Principal Investigator / Budget : 132 Lakhs
    Duration : June 2020 - March 2022

CSIR COVID-19 Project

  • Development of Ultrasensitive, Rapid and Portable system for COVID-19 screening using Label-free Raman Fingerprinting and AI (MLP 0047)
    Principal Investigator / Budget : 12 lakhs
    Duration : June 2020 - Nov 2020
  • Multiplexed lateral-flow device(s) for detection of COVID-19 (MLP0048)
    (CSIR-NllST: COVID-19 Viral RNA detection kit with ultra-bright oligoprobes for the capture and detection of viral RNA via Lateral Flow based devices)
    Co-Principal Investigator / Budget: 39 lakhs
    Duration :  Aug 2020 - March 2021