Dr. M. Arumugam

Arumugam
Professional Experience
  • Principal Scientist, October 2020 - Present
  • Senior Scientist, October 2016 - Oct 2020
  • Scientist, October 2012 - Oct 2016
  • Scientist ‘B’, DRDO-DIBER, Haldwani, October 2009 to Oct 2012
Area of Expertise
  1. Algal Biotechnology
  2. Protein Biochemistry
  3. Selenoproteins Basic biology and Applications
Achievements & Awards
  • Young Scientist, Research grant, DST-SERB, Govt. of India, 2013-2016
  • Junior Research Fellow, Indian Council of Agricultural Research (ICAR), 2000-02
  • Senior Research Fellow, Council of Scientific and Industrial Research (CSIR), 2004
  • Merit Scholarship from Government of Tamil Nadu for the year 1992-94
Patents & Publications

Patent:

  • Muthu Arumugam and Ragini Reshma. “Organic selenium enriched edible marine microalgal biomass for food, feed supplements and bioprocessing for the preparation thereof” patent filed IN, PCT, USA, JP, DE and GB.

Publications:

  • Reshma, R., Arumugam, M. (2022) Organic selenium fortification in edible marine microalga Nannochloropsis oceanica CASA CC201 for food and feed applications. Algal Research. 66, July 2022, 102787 (Accepted) https://doi.org/10.1016/j.algal.2022.102787 [IF- 5. 276]
  • Arumugam, Muthu (2022) "Advanced Technologies and Perspectives on Sustainable Microalgae Production." Frontiers in Bioengineering and Biotechnology 10.3389/fbioe.2022.841261 [IF- 5. 890]
  • Balakrishnan, Jeyakumar, Bhalram Krishnan, Thiyagarajan Sekar, Parthasarathy Ayothi, Ramkumar Muthu, Vellaikumar Sampathrajan, Arumugam Muthu, Sugasini Dhavamani, and Kathiresan Shanmugam. "Maternal supplementation of high-value PUFA-Rich Isochrysis sp. biomass prevents monosodium glutamate-induced neurotoxicity in first-generation Wistar rats." Neurochemistry International (2022): 105292. (Accepted) https://doi.org/10.1016/j.neuint.2022.105292 [IF-3.921]
  • Vimali, Elamathi, Arumugasamy Senthil Kumar, Nagamalai Sakthi Vignesh, Balasubramaniem Ashokkumar, Amarajothi Dhakshinamoorthy, Aswathy Udayan, Muthu Arumugam, Arivalagan Pugazhendhi, and Perumal Varalakshmi. (2022) "Enhancement of lipid accumulation in microalga Desmodesmus sp. VV2: Response Surface Methodology and artificial neural network modeling for biodiesel production." Chemosphere (2022): 133477. (Accepted) https://doi.org/10.1016/j.chemosphere.2021.133477 [IF-7.086]
  • Udayan, A., Sreekumar, N., & Arumugam, M. (2022). Statistical optimization and formulation of microalga cultivation medium for improved omega 3 fatty acid production. Systems Microbiology and Biomanufacturing, 1-11. (Accepted) https://doi.org/10.1007/s43393-021-00069-1
  • Vimali, E., Gunaseelan, S., Devi, V.C., Mothil, S., Arumugam, M., Ashokkumar, B., Ganeshmoorthy, I., Pugazhendhi, A. and Varalakshmi, P., 2022. Comparative study of different catalysts mediated FAME conversion from macroalga Padina tetrastromatica biomass and hydrothermal liquefaction facilitated bio-oil production. Chemosphere, p.133485. (Accepted) https://doi.org/10.1016/j.chemosphere.2021.133485 [IF-7.086]
  • Ayothi, Parthasarathy, Muthu Arumugam, and Kathiresan Shanmugam (2021) "Iron and Methyl Jasmonate Increase High Value PUFA Production by Elevating the Expression of Desaturase Genes in Marine Microalga Isochrysis sp." Journal of Applied Microbiology. 132 (3): 2042-2053. https://doi.org/10.1111/jam.15356 [IF-3.772]
  • Arumugam, M., Udayan, A., Sabapathy, H., and Abraham, B (2021) Plant growth regulator triggered metabolomic profile leading to an increased lipid accumulation in edible marine microalga. Journal of Applied Phycology 33 (3), 1353-1365. https://doi.org/10.1007/s10811-021-02424-0 [IF-3.016]
  • Thangaswamy, Sujin Jeba Kumar, Mushtaq A. Mir, and Arumugam Muthu. (2021) Green synthesis of mono and bimetallic alloy nanoparticles of gold and silver using aqueous extract of Chlorella acidophile for potential applications in sensor. Preparative Biochemistry & Biotechnology. 51(10):1026-1035. https://doi.org/10.1080/10826068.2021.1894441 [IF-1.415]
  • Sujitha, BS and M. Arumugam (2020) Targeted Metabolomic and Biochemical Changes During Nitrogen Stress Mediated Lipid Accumulation in Scenedesmus quadricauda CASA CC202. Front. Bioeng. Biotechnol. 8:585632. https://doi.org/10.3389/fbioe.2020.585632, [IF-3.644]
  • Sujin Jeba Kumar T.,V.R. Akshay., M.Vasundhara., and M. Arumugam (2020) Biosynthesis of multiphase iron nanoparticles using Syzygium aromaticum and their magnetic properties. Colloids and Surfaces A: Physicochemical and Engineering Aspects. (Article in press), https://doi.org/10.1016/j.colsurfa.2020.125241 [IF-3.999]
  • Reshma, R., Kumari, S., & Arumugam, M. (2021) Structural elucidation of selenocysteine insertion machinery of microalgal selenoprotein T and its transcriptional analysis. Biotechnology and Applied Biochemistry 68(3) 636-647. https://doi.org/10.1002/bab.1974 [IF-1.638]
  • Nagamalai Sakthi Vignesh, Elamathi Vimalia, Ramalingam Sangeetha, Muthu Arumugam, Balasubramaniem Ashokkumar, Innasimuthu Ganeshmoorthy, Perumal Varalakshmi (2020) Sustainable biofuel from microalgae: Application of lignocellulosic wastes and bio-iron nanoparticle for biodiesel production. Fuel 278. (Article in presses) https://doi.org/10.1016/j.fuel.2020.118326 [IF-5.578]
  • Udayan, A., Sabapathy, H., & Arumugam, M. (2020). Stress hormones mediated lipid accumulation and modulation of specific fatty acids in Nannochloropsis oceanica CASA CC201. Bioresource Technology, 123437. (Article in presses) https://doi.org/10.1016/j.biortech.2020.123437 [IF-7.539]
  • Vanavil, B., Selvaraj, K., Aanandhalakshmi, R., Sri, K. U., & Arumugam, M. (2020). Bioactive and thermostable sulphated polysaccharide from Sargassum swartzii with drug delivery applications. Int. J. Biol. Macromol.,153:190-200. https://doi.org/10.1016/j.ijbiomac.2020.02.332 [IF-5.162]
  • Thiyagarajan S, Arumugam M & Kathiresan S (2020) Identification and Functional Characterization of Two Novel Fatty Acid Genes from Marine Microalgae for Eicosapentaenoic Acid Production. Appl Biochem Biotechnol 190, 1371–1384. https://doi.org/10.1007/s12010-019-03176-x [IF-2.227]
  • Devi, Rajan., Nampoothiri, Kesavan., Sukumaran, Rajeev., Raveendran, Sindhu and Muthu, Arumugam. (2019). Lipase of Pseudomonas guariconesis as an additive in laundry detergent and transesterification biocatalyst. J Basic Microbiol. 60 (2): 11-125. 10.1002/jobm.201900326 [IF-1.909]
  • Balakrishnan, J., Dhavamani, S., Govindan Sadasivam, S., Arumugam, M., Vellaikumar, S., Ramalingam, J., & Shanmugam, K. (2019). Omega‐3‐rich Isochrysis sp. biomass enhances brain docosahexaenoic acid levels and improves serum lipid profile and antioxidant status in Wistar rats. J Sci Food Agric. 99(13):6066-6075. https://doi.org/10.1002/jsfa.9884 [IF-2.422]
  • Aswathy, U., Kathiresan, S., Arumugam, M (2018) Kinetin and Gibberellic acid (GA3) act synergistically to produce high value polyunsaturated fatty acids in Nannochloropsis oceanica CASA CC201. Algal Research. 32: 182-192. https://doi.org/10.1016/j.algal.2018.03.007 [IF-3.994].
  • Thiyagarajan, S., Arumugam, M., Senthil, N., Vellaikumar, S., Kathiresan S (2018). Functional characterization and substrate specificity analysis of D6-desaturase from marine microalga Isochrysis sp. Biotechnol Lett (2018) 40:577–584. https://doi.org/10.1007/s10529-017-2501-4 [IF-1.730].
  • Reshma, R. and Arumugam, M (2017). Selective degradation of the recalcitrant cell wall of Scenedesmus quadricauda CASA CC202. Planta 246 (4) 779-790. doi: 10.1007/s00425-017-2732-6. . [IF-3.361].
  • Anusree, VM., Sujitha, BS, Anand, J., Arumugam, M. (2017): Dissolved inorganic carbonate sustain the growth, lipid and biomass yield of Scenedesmus quadricauda under nitrogen starved condition. Indian J Exp Biol. 55(10): 702-710. http://10.10.100.66:8080/xmlui/handle/123456789/3183 [IF-1.165]
  • Ramya, AN., Ambily, PS., Sujitha, BS., Arumugam.M., Maiti, KK. (2017). Single cell lipid profiling of Scenedesmus quadricauda CASA-CC202 under nitrogen starved condition by surface enhanced Raman scattering (SERS) fingerprinting. Algal Research 25: 200–206. http://dx.doi.org/10.1016/j.algal.2017.05.011 [IF-4.694].
  • Moorthy, R.K., Premalatha, M., and Arumugam, M. (2017). Batch Sedimentation Studies for Freshwater Green Alga Scenedesmus abundans Using Combination of Flocculants. Frontiers in Chemistry (Section- Chemical Engineering), 5, 37. https://doi.org/10.3389/fchem.2017.00037  [IF-3.994].
  • Jawaharraj, K., Karpagam, R., Ashokkumar, B., Kathiresan, S., Moorthy, I.M.G., Arumugam, M. and Varalakshmi, P., (2017). Improved biomass and lipid production in Synechocystis sp. NN using industrial wastes and nano-catalyst coupled transesterification for biodiesel production. Bioresource Technology. 242: 128-132. 10.1016/j.biortech.2017.03.067 [IF-5.651]
  • Udayan, A. and Arumugam, M., (2017). Selective Enrichment of Eicosapentaenoic acid (20: 5n-3) in N. oceanica CASA CC201 by Natural Auxin Supplementation. Bioresource Technology. 242: 329-333. https://doi.org/10.1016/j.biortech.2017.03.149 [IF-5.651]
  • Javee, A., Sulochana, S. B., Pallissery, S. J., & Arumugam, M. (2016). Major Lipid Body Protein: A Conserved Structural Component of Lipid Body Accumulated during Abiotic Stress in S. quadricauda CASA-CC202. Frontiers in Energy Research, 4, 37. https://doi.org/10.3389/fenrg.2016.00037 [IF-2.746]
  • Sulochana, BS., Arumugam, M. (2016): Influence of abscisic acid on growth, biomass and lipid yield of Scenedesmus quadricauda under nitrogen starved condition. Biores. Technol. 213:198-203. DOI: 10.1016/j.biortech.2016.02.078 [IF-5.117]
  • Saurabh, M., Kishor, J.,Srinivasan, R., Arumugam, M., Raghavendra, R, Gupta, P., Rajeswari, H., Ajitkumar. P. (2015): NDK Interacts with FtsZ and Converts GDP to GTP to Trigger FtsZ polymerisation – A Novel Role for NDK. PLoS ONE, 10.1371/journal.pone.0143677 [IF-3.234]
  • Anand, J., Arumugam, M. (2015): Enhanced lipid accumulation and biomass yield of Scenedesmus quadricauda under nitrogen starved condition. Biores. Technol.131:246-249. https://doi.org/10.1016/j.biortech.2014.12.097 [IF-4.917]
  • Mir, MA., Arumugam, M., Mondal, S., Rajeswari, H., Ramakumar, S., Ajitkumar, P. (2014): Mycobacterium tuberculosis Cell Division Protein, FtsE, is an ATPase in Dimeric Form. The Protein Journal, 34(1):35-47. https://doi.org/10.1007/s10930-014-9593-7 [IF-2.499]
  • Ranjith, KR., Rao, HP., Arumugam, M. (2014): Lipid extraction methods from microalgae: A comprehensive review. Frontiers in Energy Research, 2, 61. https://doi.org/10.3389/fenrg.2014.00061. [IF-2.746]
  • Arumugam, M., Ajitkumar, P. (2013): Heat and SDS insensitive NDK dimers are largely stabilised by hydrophobic interaction to form functional hexamer in Mycobacterium smegmatis. Acta biochimica Polonica. 60 (2) 199–207. https://doi.org/10.18388/abp.2013_1972  [IF-2.124]
  • Arumugam, M., Agarwal, A., Arya, MC., Ahmed, Z. (2013): Influence of nitrogen sources on biomass productivity of microalgae Scenedesmus bijugatus. Biores. Technol. 131:246-249. https://doi.org/10.1016/j.biortech.2012.12.159 [IF-4.917]
  • Thomas, L., Joseph, A., Arumugam, M., Pandey, A. (2013): Production, purification, characterization and over-expression of xylanases from actinomycetes. Indina J.Exp. Biol. 51: 875-884. [IF-1.165]
  • Arumugam, M., Ajitkumar, P. (2012): Histidine 117 in the His-Gly-Ser-Asp motif is required for the biochemical activities of Nucleoside Diphosphate Kinase of Mycobacterium smegmatis. Open Biochem J. 6: 56-62. 10.2174/1874091X01206010071
  • Arumugam, M., Anand, D., Vijayarangan, N., Anbukayalvizhi, C., Rao, M., Vijay, S., Rajeswari, H., Ajitkumar, P. (2012): Nucleoside diphosphate kinase gene is expressed through multiple transcripts in Mycobacterium smegmatis. Int. J. Microbiol Res, 4 (4): 201-210. DOI:10.9735/0975-5276.4.4.201-210
  • Arumugam, M., Agarwal, A., Arya, MC., Ahmed, Z. (2011): Influence of organic and inorganic nitrogen sources on biomass yield of Scenedesmus sp. and Chlorococcum sp. Int. J. Energy Environ. 2 (6): 1125-1132
  • Arumugam, M., Agarwal, A., Arya, MC., Ahmed, Z. (2011): Microalgae: A Renewable Source for Second Generation Biofuel. Current Science. 100 (8), 1141-1142. Record Number- 20113195461 [IF-0.833]
  • Roy, S., Vijay, S., Arumugam, M., Deepak, A., Mir, MA., Ajitkumar, P. (2011): Mycobacterium tuberculosis expresses FtsE gene through multiple transcripts. Currt Microbiol.62(5),1581-1589. 10.1007/s00284-011-9897-1  [IF-1.519]
  • Prabuddha, G., Rajeswari, H., Arumugam, M., Mishra, S., Raghu, B., Praveen, A., Nagasuma, C., Srinivasan, S., Indi, S., Ajitkumar, P. (2009): Mycobacterium tuberculosis FtsZ requires at least one arginine residue at the C-Terminal end for polymerisation in vitro. Acta Biochim Biophys Sin: 42(1):58-69. DOI: 10.1093/abbs/gmp105  [IF-2.200]
PhD Awards
Name of the students with AcSIR Enrolment Number Fellowships Date of joining Thesis Title Date of degree award Current affiliation
Aswathy, U (10BB15A39022) DST-INSPIRE JRF Aug 2015 Investigation on the effect of Plant Growth Regulators on essential Omega-3 fatty acid production and its applications from Nannochloropsis oceanica CASA CC201 14 Aug 2020 Department of Chemical Engineering and Bio Engineering, Hanyang University, South Korea
Sujitha, BS (10BB14A39008) DST-INSPIRE SRF Aug 2014 Biochemical and molecular characterization of nitrogen stress mediated lipid accumulation in Scenedesmus quadricauda CASA CC202 28 May 2020 Looking for permanent faculty position in Trivandrum, Kerala only
Reshma, R (10BB15J39007) DBT-JRF Jan 2015 Identification of selenoprotein T and enrichment of organic selenium from edible microalgae for nutraceutical applications 18 May 2021 Scientist, Pulviago Private ltd, Trivandrum, Kerala.

 

Membership
  • Member in Phycology Society of America (PSA) , 2023-2025.
  • Life member in Society of Biological Chemist (SBC), India (LM. No. 2252)
  • Life member in Indian Science Congress Association (ISCA), India (L-17257)
  • Life member in Indian Association of Biomedical Scientists (IABMS), India. (LM. NO. 934/2011)
  • Life member in Biotech Research Society of India (BRSI), India
  • Life member in Association of Microbiologists of India (AMI), India. (LM ID 4670-2018)
Academic Qualification
  • Ph.D. in Microbiology and Cell Biology, Indian Institute of Science (IISc), Bangalore, in 2010.
  • M.Sc (Ag.) in Genectics and Plant Breeding, University of Agricultural Sciences (UAS), Bangalore, in 2002.
  • BSc (Ag.) from Tamil Nadu Agricultural University (TNAU), Coimbatore, in 1999.
Projects
  1. Principal Investigator for a research grant proposal to CSIR under Focused Basic Research- "Agriculture-Nutrition-Biotechnology (ANB) theme, Govt of India, MLP-0051 “Investigation on the separation, composition and utilisation of De-oiled micro algal biomass as value added nutraceuticals”. (53.00 L, for three years)
  2. Principal Investigator for a research grant proposal to DST-SERB Core Research Grant, Govt of India, CRG/2019/001913 “Investigation on identification and biochemical validation of selenoproteins from Nannochloropsis oceanica CASA CC201 as functional food/feed supplements”. (34.28 L, for three years)
  3. Principal Investigator for a research grant proposal to DBT, Govt of India, “Investigation on the synergistic effect of phytohormoes on omega3 fatty acid production from Nanochloropsis sp.”. (57.14 L for two years)
  4. Principal Investigator for a research grant proposal to DST-SERB, Govt of India, “Bioprospecting of microalgal resources for nutritionally important high value lipid production”. (5.4 L for one year)
  5. Principal Investigator for a research grant proposal to DST, Govt of India, “Biochemical and molecular investigation on stress mediated lipid accumulation and biomass productivity in microalgae”. (21 L for three years)
  6. Activity leader (Co-PI) for CSIR network project “Encapsulated Microorganisms for Environmental Protection” CSC-0127. (186 L for five years)
  7. Member for ‘DRDO-Army Biodiesel Programme’ S&T-09/DAR-71 at DIBER, DRDO. (14 Cr for five years).